rs1045642(C;C)
From SNPedia
| increased risk of cannabis dependence, lower (normal) cancer risk |
| Is a | genotype |
| of | rs1045642 |
| Gene | ABCB1 |
| Chromosome | 7 |
| Position | 87,509,329 |
| mentioned | by |
| Magnitude | 1 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1 | increased risk of cannabis dependence, lower (normal) cancer risk |
| (C;T) | 2 | Slower metaboliser for some drugs |
| (T;T) | 3 | altered drug metabolism and bioavailability; moderately increased risk for certain cancers |
Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. (2009). [1] Patients with cannabis dependence (n=40) had a significantly higher 3435C allele frequency (62.5% versus 43.8% respectively, P=0.017) and CC genotype (50% versus 20%, P=0.005, OR=4.00 [1.50-10.60]). The CC genotype was independently associated with cannabis dependence. This is the first time a significant specific genetic marker has been shown in cannabis dependence. ABCB1 polymorphisms may alter Delta9THC distribution, its psychoactive effects and individual vulnerability to dependence.
