rs104893875
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;G) | 6.5 | Parkinson's disease mutation, adult-onset |
| (G;G) | 0 | common in clinvar |
| Make rs104893875(A;A) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 89828170 |
| Gene | SNCA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs104893875 |
| dbSNP (classic) | rs104893875 |
| ClinGen | rs104893875 |
| ebi | rs104893875 |
| HLI | rs104893875 |
| Exac | rs104893875 |
| Gnomad | rs104893875 |
| Varsome | rs104893875 |
| LitVar | rs104893875 |
| Map | rs104893875 |
| PheGenI | rs104893875 |
| Biobank | rs104893875 |
| 1000 genomes | rs104893875 |
| hgdp | rs104893875 |
| ensembl | rs104893875 |
| geneview | rs104893875 |
| scholar | rs104893875 |
| rs104893875 | |
| pharmgkb | rs104893875 |
| gwascentral | rs104893875 |
| openSNP | rs104893875 |
| 23andMe | rs104893875 |
| SNPshot | rs104893875 |
| SNPdbe | rs104893875 |
| MSV3d | rs104893875 |
| GWAS Ctlg | rs104893875 |
| Max Magnitude | 6.5 |
c.136G>A (p.Glu46Lys or E46K)
Considered "probably pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal dominant Parkinson disease.
See also OMIM 163890.0004
23andMe calls this i5002552
| ClinVar | |
|---|---|
| Risk | rs104893875(A;A) |
| Alt | rs104893875(A;A) |
| Reference | Rs104893875(G;G) |
| Significance | Pathogenic |
| Disease | Lewy body dementia |
| Variation | info |
| Gene | SNCA |
| CLNDBN | Lewy body dementia |
| Reversed | 1 |
| HGVS | NC_000004.11:g.90749321C>T |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000015047.26, |
[PMID 23651603
] P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population
