rs10865331
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.4 | 1.4x higher risk for ankylosing spondylitis |
| (A;G) | 1.2 | 1.2x higher risk for ankylosing spondylitis |
| (G;G) | 0 | normal risk ankylosing spondylitis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 62324337 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10865331 |
| dbSNP (classic) | rs10865331 |
| ClinGen | rs10865331 |
| ebi | rs10865331 |
| HLI | rs10865331 |
| Exac | rs10865331 |
| Gnomad | rs10865331 |
| Varsome | rs10865331 |
| LitVar | rs10865331 |
| Map | rs10865331 |
| PheGenI | rs10865331 |
| Biobank | rs10865331 |
| 1000 genomes | rs10865331 |
| hgdp | rs10865331 |
| ensembl | rs10865331 |
| geneview | rs10865331 |
| scholar | rs10865331 |
| rs10865331 | |
| pharmgkb | rs10865331 |
| gwascentral | rs10865331 |
| openSNP | rs10865331 |
| 23andMe | rs10865331 |
| SNPshot | rs10865331 |
| SNPdbe | rs10865331 |
| MSV3d | rs10865331 |
| GWAS Ctlg | rs10865331 |
| GMAF | 0.4201 |
| Max Magnitude | 1.4 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs10865331 is a SNP in chromosomal region 2p15.
After initial GWAS reports linked this SNP to ankylosing spondylitis (AS), a follow-up study in 456 Spanish patients replicated the association between the rs10865331(A) allele and higher risk for AS (p = 0.039).
In a 2010 report, the AA genotype was associated with 1.3x odds of ankylosing spondylitis, and the GG genotype with 0.8x odds, compared to the AG genotype. [PMID 20062062
]
| GWAS snp | |
|---|---|
| PMID | [PMID 20062062]
|
| Trait | Ankylosing spondylitis |
| Title | Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci |
| Risk Allele | A |
| P-val | 2E-19 |
| Odds Ratio | 1.27 [1.18-1.37] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21743469]
|
| Trait | |
| Title | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. |
| Risk Allele | A |
| P-val | 7E-34 |
| Odds Ratio | None None |
[PMID 22138694] A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis
[PMID 20810504] Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.
[PMID 21041274] Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients.
[PMID 21068102] Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.
| GWAS snp | |
|---|---|
| PMID | [PMID 23128233]
|
| Trait | Crohn's disease |
| Title | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. |
| Risk Allele | A |
| P-val | 1E-9 |
| Odds Ratio | 1.10 [1.062-1.134] |
[PMID 27909141] Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.
[PMID 28493913] Pathogenic variants screening in seventeen candidate genes on 2p15 for association with ankylosing spondylitis in a Han Chinese population.
[PMID 31523044] Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese.
[PMID 31994481] rs10865331 in 2p15 increases susceptibility to ankylosing spondylitis: a HuGE review and meta-analysis.
