rs10883365
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1 | Normal risk of developing Crohn's disease |
| (A;G) | 1.5 | 1.2x increased risk for developing Crohn's disease |
| (G;G) | 2 | 1.62x increased risk for developing Crohn's disease |
| (T;T) | 0 |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 99528007 |
| Gene | LINC01475 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10883365 |
| dbSNP (classic) | rs10883365 |
| ClinGen | rs10883365 |
| ebi | rs10883365 |
| HLI | rs10883365 |
| Exac | rs10883365 |
| Gnomad | rs10883365 |
| Varsome | rs10883365 |
| LitVar | rs10883365 |
| Map | rs10883365 |
| PheGenI | rs10883365 |
| Biobank | rs10883365 |
| 1000 genomes | rs10883365 |
| hgdp | rs10883365 |
| ensembl | rs10883365 |
| geneview | rs10883365 |
| scholar | rs10883365 |
| rs10883365 | |
| pharmgkb | rs10883365 |
| gwascentral | rs10883365 |
| openSNP | rs10883365 |
| 23andMe | rs10883365 |
| SNPshot | rs10883365 |
| SNPdbe | rs10883365 |
| MSV3d | rs10883365 |
| GWAS Ctlg | rs10883365 |
| GMAF | 0.4752 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs10883365 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.2 (CI 1.03-1.39), and for homozygotes, 1.62 (CI 1.37-1.92). [PMID 17554300
]
[PMID 18936107] The association between rs10883365 and Crohn's disease was replicated in a Japanese population.
| GWAS | |
|---|---|
| SNP | rs10883365 |
| PubMedID | [PMID 17554261]
|
| Condition | Crohn's disease |
| Gene | NKX2-3 |
| Risk Allele | |
| pValue | 4.00E-010 |
| OR | 1.18 |
| 95% CI | 1.05-1.32 |
[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 21514341] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 19683022] Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.
[PMID 21049557] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
