||Shorter QT interval
||average QT interval
||Longer QT interval
rs10918594, a SNP near the NOS1AP gene encoding the nitric oxide synthase I protein, accounts for some of the variation seen in abnormal heart rhythms, in particular, the QT interval. Based on studies totaling ~4,000 individuals of Caucasian ancestry, homozygotes for one allele have shorter QT intervals, while homozygotes for the other allele have a longer QT interval. [PMID 16648850]
A follow-up study determined that one rs10918594(G) allele was associated with a 3.6-ms (CI: 2.7 - 4.4ms, p=6.9x10(-17)) increase in QT interval duration, and two (G) alleles had twice that increase. No increase in risk for sudden death due to a cardiac problem was associated with this SNP, though. [PMID 17576865]
[PMID 18235038] rs10494366 minor homozygotes had a 9.3 msec longer QT interval compared to major homozygotes (p=5.7x10(-5)); rs10918594 minor homozygotes had a 12.5 msec longer QT interval compared to major homozygotes (p=1.5x10(-6)). Restricting analyses to the diabetic EAs strengthened the effect despite the reduction in sample size (11.3 msec difference, p=5.1x10(-5); 13.9 msec difference, p=1.6x10(-6), respectively).
[PMID 19247217] Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
[PMID 20215044] Relationship of Common Candidate Gene Variants to Electrocardiographic T-Wave Peak to T-Wave End Interval and T-Wave Morphology Parameters
[PMID 19019189] Common candidate gene variants are associated with QT interval duration in the general population.
[PMID 21959512] Association of the rs10918594 of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms with the graft function after kidney transplantation.
[PMID 22019493] Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction.