rs10958409

rs10958409 associated with increased risk of developing intracranial aneurysm.

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)		1.79x increased aneurysm risk
(A;G)		1.37x increased aneurysm risk
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

8

Position

54414531

is a	snp
is	mentioned by
dbSNP	rs10958409
dbSNP (classic)	rs10958409
ClinGen	rs10958409
ebi	rs10958409
HLI	rs10958409
Exac	rs10958409
Gnomad	rs10958409
Varsome	rs10958409
LitVar	rs10958409
Map	rs10958409
PheGenI	rs10958409
Biobank	rs10958409
1000 genomes	rs10958409
hgdp	rs10958409
ensembl	rs10958409
geneview	rs10958409
scholar	rs10958409
google	rs10958409
pharmgkb	rs10958409
gwascentral	rs10958409
openSNP	rs10958409
23andMe	rs10958409
SNPshot	rs10958409
SNPdbe	rs10958409
MSV3d	rs10958409
GWAS Ctlg	rs10958409

GMAF

0.2163

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

23andMe blog aneurysm

• rs700651 2 G 1.18x risk 1.56x risk
• rs10958409 8 A 1.37x risk 1.79x risk
• rs1333040 9 T 1.29x risk 1.67x risk

GWAS snp
PMID	[PMID 18997786]
Trait	Intracranial aneurysm
Title	Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele	A
P-val	1E-10
Odds Ratio	1.36 [1.24-1.49]

OMIM	612587
Desc	ANEURYSM, INTRACRANIAL BERRY, 10
Variant
Related	also

[PMID 20190001] The Relationship Between Smoking and Replicated Sequence Variants on Chromosomes 8 and 9 With Familial Intracranial Aneurysm

[PMID 20395613] Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.

Brain Aneurysm

[PMID 22476622] Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.

[PMID 23733552] Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.