rs11212617
From SNPedia
| influences Metformin response |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal response to Metformin |
| (A;C) | 1.5 | Somewhat increased likelihood of treatment success with metformin |
| (C;C) | 1.5 | Somewhat increased likelihood of treatment success with metformin |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 108412434 |
| Gene | C11orf65 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11212617 |
| dbSNP (classic) | rs11212617 |
| ClinGen | rs11212617 |
| ebi | rs11212617 |
| HLI | rs11212617 |
| Exac | rs11212617 |
| Gnomad | rs11212617 |
| Varsome | rs11212617 |
| LitVar | rs11212617 |
| Map | rs11212617 |
| PheGenI | rs11212617 |
| Biobank | rs11212617 |
| 1000 genomes | rs11212617 |
| hgdp | rs11212617 |
| ensembl | rs11212617 |
| geneview | rs11212617 |
| scholar | rs11212617 |
| rs11212617 | |
| pharmgkb | rs11212617 |
| gwascentral | rs11212617 |
| openSNP | rs11212617 |
| 23andMe | rs11212617 |
| SNPshot | rs11212617 |
| SNPdbe | rs11212617 |
| MSV3d | rs11212617 |
| GWAS Ctlg | rs11212617 |
| GMAF | 0.4706 |
| Max Magnitude | 1.5 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
| This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
Influences Metformin response
| GWAS snp | |
|---|---|
| PMID | [PMID 21186350 ]
|
| Trait | |
| Title | Common variants neat ATM are associated with glycemic response to metformin in type 2 diabetes |
| Risk Allele | C |
| P-val | 3E-9 |
| Odds Ratio | 1.3500 [1.22-1.49] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21845381] |
| Trait | |
| Title | Does metformin work for everyone? A genome-wide association study for metformin response. |
| Risk Allele | A |
| P-val | 3E-9 |
| Odds Ratio | None None |
[PMID 22453232] A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
[PMID 23171036] Metformin: a cheap and well-tolerated drug that provides benefits for viral infections
[PMID 22751958] The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
| ClinVar | |
|---|---|
| Risk | Rs11212617(A;A) |
| Alt | Rs11212617(A;A) |
| Reference | Rs11212617(C;C) |
| Significance | Drug-response |
| Disease | metformin response - Efficacy |
| Variation | info |
| Gene | C11orf65 |
| CLNDBN | metformin response - Efficacy |
| Reversed | 0 |
| HGVS | NC_000011.9:g.108283161C>A |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211248.1, |
