rs1131341
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 |
| Make rs1131341(C;T) |
| Make rs1131341(T;T) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 16 |
| Position | 69714966 |
| Gene | NQO1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1131341 |
| dbSNP (classic) | rs1131341 |
| ClinGen | rs1131341 |
| ebi | rs1131341 |
| HLI | rs1131341 |
| Exac | rs1131341 |
| Gnomad | rs1131341 |
| Varsome | rs1131341 |
| LitVar | rs1131341 |
| Map | rs1131341 |
| PheGenI | rs1131341 |
| Biobank | rs1131341 |
| 1000 genomes | rs1131341 |
| hgdp | rs1131341 |
| ensembl | rs1131341 |
| geneview | rs1131341 |
| scholar | rs1131341 |
| rs1131341 | |
| pharmgkb | rs1131341 |
| gwascentral | rs1131341 |
| openSNP | rs1131341 |
| 23andMe | rs1131341 |
| SNPshot | rs1131341 |
| SNPdbe | rs1131341 |
| MSV3d | rs1131341 |
| GWAS Ctlg | rs1131341 |
| GMAF | 0.01699 |
| Max Magnitude | 0 |
rs1131341 (C465T, Arg139Trp) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Trp (T) at this location denotes the NQO1*3 allele.
per [pharmgkb], the NQ1*3 allele is associated with reduced enzyme activity
[PMID 16266898] T allele strongly associated (OR = 6.36, CI = 1.84 - 21.90, p = 0.002) with infant acute lymphoblastic leukemia among 103 case infants and 185 controls
| ? | (C;C) (C;T) | |
|---|---|---|
|
| ||
[PMID 15576619
] Hematotoxicity in workers exposed to low levels of benzene.
[PMID 17885617] Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 18632753] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.
[PMID 18922824] Genetic susceptibility to childhood leukaemia.
[PMID 18992148] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
[PMID 20663217] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.
[PMID 23054000] Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.
[PMID 23175176] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.
[PMID 24830960] Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer
