rs11466345

Orientation

minus

Stabilized

minus

Make rs11466345(A;A)

Make rs11466345(A;G)

Make rs11466345(G;G)

Reference

GRCh38 38.1/141

Chromosome

19

Position

41337556

Gene

TGFB1

is a	snp
is	mentioned by
dbSNP	rs11466345
dbSNP (classic)	rs11466345
ClinGen	rs11466345
ebi	rs11466345
HLI	rs11466345
Exac	rs11466345
Gnomad	rs11466345
Varsome	rs11466345
LitVar	rs11466345
Map	rs11466345
PheGenI	rs11466345
Biobank	rs11466345
1000 genomes	rs11466345
hgdp	rs11466345
ensembl	rs11466345
geneview	rs11466345
scholar	rs11466345
google	rs11466345
pharmgkb	rs11466345
gwascentral	rs11466345
openSNP	rs11466345
23andMe	rs11466345
SNPshot	rs11466345
SNPdbe	rs11466345
MSV3d	rs11466345
GWAS Ctlg	rs11466345

GMAF

0.1529

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 18281501] colorectal neoplasia

271 colorectal adenoma cases and 544 controls, and 535 colorectal adenocarcinoma cases and 656 controls.

• rs6957(A) was associated with higher serum TGFbeta-1 [means (in ng/mL) and 95% confidence interval (95% CI) for AA or AG, 32.6 (30.6-34.7); GG, 29.0 (25.1-32.9); P(difference) = 0.05]
• rs11466345(G;G) had a statistically significantly lower risk of adenocarcinoma [AG versus AA: odds ratio (OR), 0.9 (95% CI, 0.7-1.2); GG versus AA: OR, 0.4 (95% CI, 0.2-0.7); P(trend) = 0.01].
• The haplotype carrying both variants was also statistically significantly associated with a reduced risk of adenocarcinoma (OR, 0.3; 95% CI, 0.1-0.8)

[PMID 23059779] A Study of Ethnic Differences in TGFβ1 Gene Polymorphisms and Effects on the Risk of Radiation Pneumonitis in Non-Small-Cell Lung Cancer

[PMID 31586488] Effect of gene polymorphisms in ADAM33, TGFβ1, VEGFA, and PLAUR on asthma in Thai population.