rs11574637

Orientation

plus

Stabilized

plus

Make rs11574637(C;C)

Make rs11574637(C;T)

Make rs11574637(T;T)

Reference

GRCh38 38.1/141

Chromosome

16

Position

31357553

Gene

ITGAX

is a	snp
is	mentioned by
dbSNP	rs11574637
dbSNP (classic)	rs11574637
ClinGen	rs11574637
ebi	rs11574637
HLI	rs11574637
Exac	rs11574637
Gnomad	rs11574637
Varsome	rs11574637
LitVar	rs11574637
Map	rs11574637
PheGenI	rs11574637
Biobank	rs11574637
1000 genomes	rs11574637
hgdp	rs11574637
ensembl	rs11574637
geneview	rs11574637
scholar	rs11574637
google	rs11574637
pharmgkb	rs11574637
gwascentral	rs11574637
openSNP	rs11574637
23andMe	rs11574637
SNPshot	rs11574637
SNPdbe	rs11574637
MSV3d	rs11574637
GWAS Ctlg	rs11574637

GMAF

0.1579

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

Associated with systemic lupus erythematosus (SLE) [PMID 18204098]

GWAS
SNP	rs11574637
PubMedID	[PMID 18204098]
Condition	Systemic lupus erythematosus
Gene	ITGAM, ITGAX
Risk Allele	C
pValue	3.00E-011
OR	1.33
95% CI	1.22-1.46

OMIM	609939
Desc	SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 6; SLEB6
Variant
Related	also

OMIM	151510
Desc	INTEGRIN, ALPHA-X; ITGAX
Variant
Related	also

[PMID 21362770] Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts

[PMID 19129174] Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

[PMID 19286673] ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.

[PMID 19997561] Identification of MAMDC1 as a candidate susceptibility gene for systemic lupus erythematosus (SLE).

[PMID 20629846] Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.