rs1165205
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.5 | 0.85x decreased gout risk |
| (A;T) | 1.4 | 0.85x decreased gout risk |
| (T;T) | 1 | normal |
| Reference | GRCh38 38.1/142 |
| Chromosome | 6 |
| Position | 25870314 |
| Gene | SLC17A3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1165205 |
| dbSNP (classic) | rs1165205 |
| ClinGen | rs1165205 |
| ebi | rs1165205 |
| HLI | rs1165205 |
| Exac | rs1165205 |
| Gnomad | rs1165205 |
| Varsome | rs1165205 |
| LitVar | rs1165205 |
| Map | rs1165205 |
| PheGenI | rs1165205 |
| Biobank | rs1165205 |
| 1000 genomes | rs1165205 |
| hgdp | rs1165205 |
| ensembl | rs1165205 |
| geneview | rs1165205 |
| scholar | rs1165205 |
| rs1165205 | |
| pharmgkb | rs1165205 |
| gwascentral | rs1165205 |
| openSNP | rs1165205 |
| 23andMe | rs1165205 |
| SNPshot | rs1165205 |
| SNPdbe | rs1165205 |
| MSV3d | rs1165205 |
| GWAS Ctlg | rs1165205 |
| GMAF | 0.2824 |
| Max Magnitude | 1.5 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1165205 is a SNP in the SLC17A3 gene on ch 6.
A large study totaling 7,699 participants in the Framingham cohort and 4,148 participants in the Rotterdam cohort was conducted, with genome-wide significant SNPs then replicated in 11,000+ Caucasian and ~4,000 African-American individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). This study calculated an odds ratio of 0.85 for rs1165205, (CI: 0.77-0.94, p = 0.002). A genetic score comprised of this SNP plus 2 others may stratify risk for gout. [PMID 18834626
]
See also: 23andMe blog gout
- rs2231142(T) 1.7x
- rs16890979(C) 1.7x
- rs1165205(A) 1.2x
| OMIM | 612671 |
| Desc | URIC ACID CONCENTRATION, SERUM, QUANTITATIVE TRAIT LOCUS 3; UAQTL4 |
| Variant | |
| Related | also |
[PMID 19503597] Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
[PMID 19890391] Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease.
[PMID 20053405] Sex and age interaction with genetic association of atherogenic uric acid concentrations.
[PMID 20470424] A three-stage approach for genome-wide association studies with family data for quantitative traits.
[PMID 21765209] Serum and cerebrospinal fluid uric acid levels in lewy body disorders: associations with disease occurrence and amyloid-beta pathway.
[PMID 25867401] Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population
[PMID 27511497] Association analysis of five SNP variants with gout in the Minnan population in China.
