rs11978267

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	0	normal/common
(G;G)	2	possible increased risk for infant acute myeloid leukemia (AML)

Make rs11978267(A;G)

Reference

GRCh38 38.1/141

Chromosome

7

Position

50398606

Gene

IKZF1

is a	snp
is	mentioned by
dbSNP	rs11978267
dbSNP (classic)	rs11978267
ClinGen	rs11978267
ebi	rs11978267
HLI	rs11978267
Exac	rs11978267
Gnomad	rs11978267
Varsome	rs11978267
LitVar	rs11978267
Map	rs11978267
PheGenI	rs11978267
Biobank	rs11978267
1000 genomes	rs11978267
hgdp	rs11978267
ensembl	rs11978267
geneview	rs11978267
scholar	rs11978267
google	rs11978267
pharmgkb	rs11978267
gwascentral	rs11978267
openSNP	rs11978267
23andMe	rs11978267
SNPshot	rs11978267
SNPdbe	rs11978267
MSV3d	rs11978267
GWAS Ctlg	rs11978267

GMAF

0.2282

Max Magnitude

2

?	(A;A) (A;G) (G;G)	28

GWAS snp
PMID	[PMID 19684603]
Trait	Acute lymphoblastic leukemia (childhood)
Title	Germline genomic variants associated with childhood acute lymphoblastic leukemia
Risk Allele	G
P-val	8E-11
Odds Ratio	1.69 [1.40-1.90]

OMIM	613067
Desc
Variant
Related	also

[PMID 22422485] Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report

[PMID 23692655] ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

[PMID 24564228] ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

[PMID 28768142] Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.

[PMID 31604453] IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study.