rs11986220
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs11986220(A;A) |
| Make rs11986220(A;T) |
| Make rs11986220(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 127519444 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11986220 |
| dbSNP (classic) | rs11986220 |
| ClinGen | rs11986220 |
| ebi | rs11986220 |
| HLI | rs11986220 |
| Exac | rs11986220 |
| Gnomad | rs11986220 |
| Varsome | rs11986220 |
| LitVar | rs11986220 |
| Map | rs11986220 |
| PheGenI | rs11986220 |
| Biobank | rs11986220 |
| 1000 genomes | rs11986220 |
| hgdp | rs11986220 |
| ensembl | rs11986220 |
| geneview | rs11986220 |
| scholar | rs11986220 |
| rs11986220 | |
| pharmgkb | rs11986220 |
| gwascentral | rs11986220 |
| openSNP | rs11986220 |
| 23andMe | rs11986220 |
| SNPshot | rs11986220 |
| SNPdbe | rs11986220 |
| MSV3d | rs11986220 |
| GWAS Ctlg | rs11986220 |
| GMAF | 0.1038 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
10.1371 PLOS reports that rs11986220 in 8q24 resides within a FoxA1 binding site, with the prostate cancer risk allele facilitating both stronger FoxA1 binding and stronger androgen responsiveness, due to the A allele forming a more perfect FoxA1/HNF3? binding site than the T allele. Nearby rs6983267 is a succeptibility marker for prostate cancer and colon cancer.
[PMID 19680443
] Functional enhancers at the gene-poor 8q24 cancer-linked locus
[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.
