|(G;G)||0||common in clinvar|
rs1208 is a SNP in the NAT2 gene, potentially encoding a variant detoxifying protein known as an N-acetyltransferase, but which NAT2 variant depends on which other NAT2 SNPs were also inherited. See the discussion of the NAT2 gene for a more complete explanation.
The risk allele for this SNP is rs1208(G).
[PMID 21989592] Interactions of cigarette smoking with NAT2 polymorphisms impact rheumatoid arthritis risk in African Americans
[PMID 22092036] Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
[PMID 20459474] Can we predict top-level sports performance in power vs endurance events? A genetic approach
|Disease||Slow acetylator due to N-acetyltransferase enzyme variant|
|CLNDBN||Slow acetylator due to N-acetyltransferase enzyme variant|
|CLNSRC||OMIM Allelic Variant|
[PMID 14724163] Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.
[PMID 16112301] NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.
[PMID 16416399] Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
[PMID 16847422] Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma.
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 18664443] Unraveling ambiguous NAT2 genotyping data.
[PMID 18680467] Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.
[PMID 18773084] Multiple advantageous amino acid variants in the NAT2 gene in human populations.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 20043821] Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data.
[PMID 2068113] Diverse point mutations in the human gene for polymorphic N-acetyltransferase.
[PMID 6721992] A simple test for acetylator phenotype using caffeine.
[PMID 8807666] NAT2*12A (803A-->G) codes for rapid arylamine n-acetylation in humans.
[PMID 24939416] CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients
[PMID 25798622] Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene