rs12143842
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal | |
| (C;T) | 4.4ms QT interval duration increase on average | |
| (T;T) | 8.8ms QT interval duration increase on average |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 162064100 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs12143842 |
| dbSNP (classic) | rs12143842 |
| ClinGen | rs12143842 |
| ebi | rs12143842 |
| HLI | rs12143842 |
| Exac | rs12143842 |
| Gnomad | rs12143842 |
| Varsome | rs12143842 |
| LitVar | rs12143842 |
| Map | rs12143842 |
| PheGenI | rs12143842 |
| Biobank | rs12143842 |
| 1000 genomes | rs12143842 |
| hgdp | rs12143842 |
| ensembl | rs12143842 |
| geneview | rs12143842 |
| scholar | rs12143842 |
| rs12143842 | |
| pharmgkb | rs12143842 |
| gwascentral | rs12143842 |
| openSNP | rs12143842 |
| 23andMe | rs12143842 |
| SNPshot | rs12143842 |
| SNPdbe | rs12143842 |
| MSV3d | rs12143842 |
| GWAS Ctlg | rs12143842 |
| GMAF | 0.2429 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs12143842 is a SNP within 100kb of the NOS1AP gene.
A study of participants in the Rotterdam Study, a population-based, prospective cohort study of individuals >/=55 years of age, concluded that each rs12143842(T) allele was associated with a QT-interval duration increase of 4.4-ms (p =4.4x10e-28). This SNP is the most strongly associated with QT interval of all known to date (at the time of publication). [PMID 18927126]
| GWAS snp | |
|---|---|
| PMID | [PMID 19305408 ]
|
| Trait | QT interval |
| Title | Common variants at ten loci influence QT interval duation in the QTGEN Study |
| Risk Allele | T |
| P-val | 2E-78 |
| Odds Ratio | 3.15 [2.81-3.49] msec increase |
| GWAS snp | |
|---|---|
| PMID | [PMID 19305409]
|
| Trait | QT interval |
| Title | Common variants at ten loci modulate the QT interval duration in the QTSCD Study |
| Risk Allele | T |
| P-val | 2E-78 |
| Odds Ratio | 2.88 [2.43-3.33] ms increase |
Publications[edit]
[PMID 31747862] Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death.
[PMID 28827735] The genetic variation rs12143842 in NOS1AP increases idiopathic ventricular tachycardia risk in Chinese Han populations.
[PMID 26332198] NOS1AP polymorphisms modify QTc interval duration but not cardiac arrest risk in hypertrophic cardiomyopathy
[PMID 25819866] Genetic markers of repolarization and arrhythmic events after acute coronary syndromes
[PMID 24096169] Single nucleotide polymorphisms in arrhythmia genes modify the risk of cardiac events and sudden death in long QT syndrome
[PMID 23166209] The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans
[PMID 23092954] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.
[PMID 20722683] A common variant of NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes
[PMID 19587794] Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies
