rs12316150
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs12316150(A;A) |
| Make rs12316150(A;T) |
| Make rs12316150(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 10159692 |
| Gene | OLR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs12316150 |
| dbSNP (classic) | rs12316150 |
| ClinGen | rs12316150 |
| ebi | rs12316150 |
| HLI | rs12316150 |
| Exac | rs12316150 |
| Gnomad | rs12316150 |
| Varsome | rs12316150 |
| LitVar | rs12316150 |
| Map | rs12316150 |
| PheGenI | rs12316150 |
| Biobank | rs12316150 |
| 1000 genomes | rs12316150 |
| hgdp | rs12316150 |
| ensembl | rs12316150 |
| geneview | rs12316150 |
| scholar | rs12316150 |
| rs12316150 | |
| pharmgkb | rs12316150 |
| gwascentral | rs12316150 |
| openSNP | rs12316150 |
| 23andMe | rs12316150 |
| SNPshot | rs12316150 |
| SNPdbe | rs12316150 |
| MSV3d | rs12316150 |
| GWAS Ctlg | rs12316150 |
| GMAF | 0.04821 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs12316150, a SNP also known as +1071, is located in the 3' untranslated region of the oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 gene, which is also known as the LOX-1 gene.
The rs12316150 risk allele has been associated with increased risk for Alzheimer's disease in several studies of ~200 Southern Italian Alzheimer patients, but only within the context of a haplotype including one or both of neighboring SNPs rs1050283 and rs669.[PMID 15860461, PMID 18191876]
| ClinVar | |
|---|---|
| Risk | rs12316150(T;T) |
| Alt | rs12316150(T;T) |
| Reference | rs12316150(A;A) |
| Significance | Other |
| Disease | Myocardial infarction |
| Variation | info |
| Gene | OLR1 |
| CLNDBN | Myocardial infarction |
| Reversed | 0 |
| HGVS | NC_000012.11:g.10312291A\x3d |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000007410.4, |
