rs12425791
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | possibly increased risk of stroke | |
| (A;G) | mixed evidence of increased risk for stroke | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 674318 |
| Gene | LOC105369597 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs12425791 |
| dbSNP (classic) | rs12425791 |
| ClinGen | rs12425791 |
| ebi | rs12425791 |
| HLI | rs12425791 |
| Exac | rs12425791 |
| Gnomad | rs12425791 |
| Varsome | rs12425791 |
| LitVar | rs12425791 |
| Map | rs12425791 |
| PheGenI | rs12425791 |
| Biobank | rs12425791 |
| 1000 genomes | rs12425791 |
| hgdp | rs12425791 |
| ensembl | rs12425791 |
| geneview | rs12425791 |
| scholar | rs12425791 |
| rs12425791 | |
| pharmgkb | rs12425791 |
| gwascentral | rs12425791 |
| openSNP | rs12425791 |
| 23andMe | rs12425791 |
| SNPshot | rs12425791 |
| SNPdbe | rs12425791 |
| MSV3d | rs12425791 |
| GWAS Ctlg | rs12425791 |
| GMAF | 0.2016 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs12425791 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs11833579.
Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. [PMID 19369658
]
Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.[1]
| GWAS snp | |
|---|---|
| PMID | [PMID 19369658]
|
| Trait | Stroke |
| Title | Genomewide Association Studies of Stroke |
| Risk Allele | A |
| P-val | 1E-9 |
| Odds Ratio | |
[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
[PMID 22212150] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
[PMID 22429733] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
[PMID 20448654] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
[PMID 21148441] Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies.
[PMID 21376321] No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
[PMID 22297388] Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
[PMID 23270316] Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis
[PMID 23596786] [Correlation study on 12p13 single nucleotide polymorphism rs12425791 and Chinese medical syndrome types in ischemic stroke patients of the Han nationality]
[PMID 22938733] Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population
[PMID 22795341] The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.
[PMID 26312640] Impact of chromosome 12p13 variants on ischemic stroke risk
[PMID 26687183] A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.
