rs12593813

plus

Geno	Mag	Summary
(A;A)	2	<0.71x risk for restless legs
(A;G)	1.5	0.71x risk for restless legs
(G;G)	1	normal risk of restless leg syndrome

Reference

GRCh38 38.1/141

Chromosome

15

Position

67744514

Gene

MAP2K5

is a	snp
is	mentioned by
dbSNP	rs12593813
dbSNP (classic)	rs12593813
ClinGen	rs12593813
ebi	rs12593813
HLI	rs12593813
Exac	rs12593813
Gnomad	rs12593813
Varsome	rs12593813
LitVar	rs12593813
Map	rs12593813
PheGenI	rs12593813
Biobank	rs12593813
1000 genomes	rs12593813
hgdp	rs12593813
ensembl	rs12593813
geneview	rs12593813
scholar	rs12593813
google	rs12593813
pharmgkb	rs12593813
gwascentral	rs12593813
openSNP	rs12593813
23andMe	rs12593813
SNPshot	rs12593813
SNPdbe	rs12593813
MSV3d	rs12593813
GWAS Ctlg	rs12593813

GMAF

0.4545

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

rs12593813, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (A) minor allele. [PMID 17637780]

GWAS
SNP	rs12593813
PubMedID	[PMID 17637780]
Condition	Restless legs syndrome
Gene	MAP2K5, LBXCOR1
Risk Allele	G
pValue	1.00E-015
OR	1.5
95% CI	1.36-1.66

[PMID 19223043] Exploring the genetic link between RLS and ADHD

GWAS snp
PMID	[PMID 21779176 ]
Trait
Title	Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
Risk Allele	G
P-val	1E-22
Odds Ratio	1.4100 [1.32-1.52]

Restless Legs Syndrome: Preliminary Research

[PMID 23543094 ] Testing for associations between loci and environmental gradients using latent factor mixed models.