rs1265181
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;G) | 2 | increased risk for psoriasis |
| (G;G) | 2.5 | possibly increased risk of psoriasis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 31188008 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1265181 |
| dbSNP (classic) | rs1265181 |
| ClinGen | rs1265181 |
| ebi | rs1265181 |
| HLI | rs1265181 |
| Exac | rs1265181 |
| Gnomad | rs1265181 |
| Varsome | rs1265181 |
| LitVar | rs1265181 |
| Map | rs1265181 |
| PheGenI | rs1265181 |
| Biobank | rs1265181 |
| 1000 genomes | rs1265181 |
| hgdp | rs1265181 |
| ensembl | rs1265181 |
| geneview | rs1265181 |
| scholar | rs1265181 |
| rs1265181 | |
| pharmgkb | rs1265181 |
| gwascentral | rs1265181 |
| openSNP | rs1265181 |
| 23andMe | rs1265181 |
| SNPshot | rs1265181 |
| SNPdbe | rs1265181 |
| MSV3d | rs1265181 |
| GWAS Ctlg | rs1265181 |
| GMAF | 0.1102 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1265181 is a SNP in the HLA region of chromosome 6.
A large study (>6,000 Chinese psoriasis patients and an equal number of controls) found a highly significant association between the minor rs1265181(G) allele and risk for psoriasis.[PMID 19169255] A proxy for this allele is rs1265159(A).
See also: 23andMe blog psoriasis
| GWAS snp | |
|---|---|
| PMID | [PMID 19169255] |
| Trait | Psoriasis |
| Title | Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21 |
| Risk Allele | |
| P-val | NS |
| Odds Ratio | 22.62 None |
[PMID 21208785] Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population
[PMID 19680446
] Multiple Loci within the major histocompatibility complex confer risk of psoriasis.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20606885] Genetics of psoriasis and psoriatic arthritis.
[PMID 27073425] Candidate gene polymorphisms and risk of psoriasis: A pilot study
