| Geno
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Mag
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Summary
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| (C;C)
|
|
4x more likely to have blond hair
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| (C;T)
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2x more likely to have blond hair
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| (T;T)
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0
|
normal
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A 2007 study based on the Icelanders and Dutch concluded that individuals with an rs12821256(C) allele were ~2x fold more likely to have blond than brown hair color. The specific odds ratio claimed per (C) allele is 2.32, p = 5.5 x 10-14.[PMID 17952075]
[PMID 24880339
] A molecular basis for classic blond hair color in Europeans: This article shows how changing just rs12821256 from (T) to (C) in a transgenic mouse leads to lighter hair color.
| OMIM | 611664 |
| Desc | SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 7; SHEP7 |
| Variant | |
| Related | also |
[PMID 18483556] A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
[PMID 20042077] Genetic determinants of hair and eye colours in the Scottish and Danish populations.
[PMID 20585627] Web-based, participant-driven studies yield novel genetic associations for common traits.
| GWAS snp
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| PMID
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[PMID 23548203]
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| Trait
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Hair color
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| Title
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Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
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| Risk Allele
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C
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| P-val
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7E-19
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| Odds Ratio
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.18 [0.14-0.22] unit increase
|
] A molecular basis for classic blond hair color in Europeans: This article shows how changing just rs12821256 from (T) to (C) in a transgenic mouse leads to lighter hair color.
