rs12896399

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(T;T)		Lighter hair color & blue eyes more likely

Make rs12896399(G;G)

Make rs12896399(G;T)

Reference

GRCh38 38.1/141

Chromosome

14

Position

92307319

Gene	LOC105370627

is a	snp
is	mentioned by
dbSNP	rs12896399
dbSNP (classic)	rs12896399
ClinGen	rs12896399
ebi	rs12896399
HLI	rs12896399
Exac	rs12896399
Gnomad	rs12896399
Varsome	rs12896399
LitVar	rs12896399
Map	rs12896399
PheGenI	rs12896399
Biobank	rs12896399
1000 genomes	rs12896399
hgdp	rs12896399
ensembl	rs12896399
geneview	rs12896399
scholar	rs12896399
google	rs12896399
pharmgkb	rs12896399
gwascentral	rs12896399
openSNP	rs12896399
23andMe	rs12896399
SNPshot	rs12896399
SNPdbe	rs12896399
MSV3d	rs12896399
GWAS Ctlg	rs12896399

GMAF

0.2893

Max Magnitude

0

?	(G;G) (G;T) (T;T)	28

10.1371/journal.pgen.1000074 associated with hair color rs12896399 rs12203592

10.1371/journal.pgen.1000993

GWAS snp
PMID	[PMID 18483556]
Trait	Black vs. blond hair color
Title	A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
Risk Allele	G
P-val	7.9999999999999993E-21
Odds Ratio	0.18 [0.14-0.22] increase in hair color score

GWAS snp
PMID	[PMID 17952075]
Trait	Blond vs. brown hair
Title	Genetic determinants of hair, eye and skin pigmentation in Europeans
Risk Allele	T
P-val	9.9999999999999997E-49
Odds Ratio	2.56 [2.12-3.09]

OMIM	210750
Desc	SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6; SHEP6
Variant
Related	also

OMIM	609840
Desc	SOLUTE CARRIER FAMILY 24 (SODIUM/POTASSIUM/CALCIUM EXCHANGER), MEMBER
Variant
Related	also

GWAS snp
PMID	[PMID 20585627]
Trait	Eye color
Title	Web-based, participant-driven studies yield novel genetic associations for common traits
Risk Allele	G
P-val	2E-23
Odds Ratio	1.73 [NR]

OMIM	609840
Desc
Variant	0001
Related	also

[PMID 19609347] A genome-wide association study of hypertension and blood pressure in African Americans.

[PMID 19884608] Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.

[PMID 20463881] Digital quantification of human eye color highlights genetic association of three new loci.

GWAS snp
PMID	[PMID 23548203]
Trait	Eye color
Title	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
Risk Allele	G
P-val	3E-7
Odds Ratio	.27 [0.17-0.37] unit decrease

[PMID 23771755] Improved eye- and skin-color prediction based on 8 SNPs.

ClinVar
Risk	Rs12896399(T;T)
Alt	Rs12896399(T;T)
Reference	rs12896399(G;G)
Significance	Other
Disease	Skin/hair/eye pigmentation
Variation	info
Gene	LOC105370627
CLNDBN	Skin/hair/eye pigmentation, variation in, 6
Reversed	0
HGVS	NC_000014.8:g.92773663G>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000001485.5,