rs1295686
| Orientation | minus |
| Stabilized | minus |
| Make rs1295686(A;A) |
| Make rs1295686(A;G) |
| Make rs1295686(G;G) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 5 |
| Position | 132660151 |
| Gene | IL13 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1295686 |
| dbSNP (classic) | rs1295686 |
| ClinGen | rs1295686 |
| ebi | rs1295686 |
| HLI | rs1295686 |
| Exac | rs1295686 |
| Gnomad | rs1295686 |
| Varsome | rs1295686 |
| LitVar | rs1295686 |
| Map | rs1295686 |
| PheGenI | rs1295686 |
| Biobank | rs1295686 |
| 1000 genomes | rs1295686 |
| hgdp | rs1295686 |
| ensembl | rs1295686 |
| geneview | rs1295686 |
| scholar | rs1295686 |
| rs1295686 | |
| pharmgkb | rs1295686 |
| gwascentral | rs1295686 |
| openSNP | rs1295686 |
| 23andMe | rs1295686 |
| SNPshot | rs1295686 |
| SNPdbe | rs1295686 |
| MSV3d | rs1295686 |
| GWAS Ctlg | rs1295686 |
| GMAF | 0.388 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 20860503 ]
|
| Trait | |
| Title | A large-scale, consortium-based genomewide association study of asthma |
| Risk Allele | T |
| P-val | 1E-7 |
| Odds Ratio | 1.15 [1.09-1.20] |
[PMID 21050946] Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE
[PMID 22515947] Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery
[PMID 22075330] A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study
[PMID 15660293] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
[PMID 17303794] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.
[PMID 17346294] IL13 gene polymorphism association with cord serum immunoglobulin E.
[PMID 18056382] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.
[PMID 18186920] IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.
[PMID 18410415] Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.
[PMID 18625055] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19956101] Overview of the Rapid Response data.
[PMID 19956102] Evidence for association of the TCF7 locus with type I diabetes.
[PMID 19956109] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
[PMID 20015396] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.
[PMID 20403202] Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study.
[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.
[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
| GWAS snp | |
|---|---|
| PMID | [PMID 23042114] |
| Trait | Atopic dermatitis |
| Title | Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. |
| Risk Allele | T |
| P-val | 2E-6 |
| Odds Ratio | 1.22 [NR] |
[PMID 23841068] Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis
| GWAS snp | |
|---|---|
| PMID | [PMID 23886662]
|
| Trait | Atopic dermatitis |
| Title | A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. |
| Risk Allele | A |
| P-val | 2E-17 |
| Odds Ratio | 1.38 [1.283-1.49] |
[PMID 23028483] Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
| GWAS snp | |
|---|---|
| PMID | [PMID 24241537] |
| Trait | Asthma (childhood, severe) |
| Title | A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. |
| Risk Allele | T |
| P-val | 2E-6 |
| Odds Ratio | 1.31 [1.17-1.48] |
[PMID 26365633] Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese
[PMID 29017771] Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus.
[PMID 32678078] Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium.
