rs13281615
| Orientation | plus |
| Stabilized | plus |
| Make rs13281615(A;A) |
| Make rs13281615(A;G) |
| Make rs13281615(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 127343372 |
| Gene | CASC21, CASC8 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs13281615 |
| dbSNP (classic) | rs13281615 |
| ClinGen | rs13281615 |
| ebi | rs13281615 |
| HLI | rs13281615 |
| Exac | rs13281615 |
| Gnomad | rs13281615 |
| Varsome | rs13281615 |
| LitVar | rs13281615 |
| Map | rs13281615 |
| PheGenI | rs13281615 |
| Biobank | rs13281615 |
| 1000 genomes | rs13281615 |
| hgdp | rs13281615 |
| ensembl | rs13281615 |
| geneview | rs13281615 |
| scholar | rs13281615 |
| rs13281615 | |
| pharmgkb | rs13281615 |
| gwascentral | rs13281615 |
| openSNP | rs13281615 |
| 23andMe | rs13281615 |
| SNPshot | rs13281615 |
| SNPdbe | rs13281615 |
| MSV3d | rs13281615 |
| GWAS Ctlg | rs13281615 |
| GMAF | 0.4826 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
- rs13281615 in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively) and improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97).
[PMID 19005751] rs13281615 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.17, p(allelic) = 1.8 x 10e-2) for breast cancer
| GWAS | |
|---|---|
| SNP | rs13281615 |
| PubMedID | [PMID 17529967 ]
|
| Condition | Breast cancer |
| Gene | Intergenic |
| Risk Allele | T |
| pValue | 5.00E-012 |
| OR | 1.08 |
| 95% CI | 1.05-1.11 |
[PMID 19656774] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease
[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk
[PMID 20699374] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
[PMID 21051319] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21814516] A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression
[PMID 22087758] Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) study
[PMID 22726230] Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer
[PMID 17618282] A common genetic risk factor for colorectal and prostate cancer.
[PMID 17997823] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.
[PMID 18535017] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18612136] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
[PMID 18625567] Association of chromosomal locus 8q24 and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.
[PMID 18681954] Breast cancer susceptibility loci and mammographic density.
[PMID 18704501] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
[PMID 18708391] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
[PMID 18772892] Can genes for mammographic density inform cancer aetiology?
[PMID 18785201] Novel breast cancer risk alleles and endometrial cancer risk.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19088016] Genetic susceptibility loci for breast cancer by estrogen receptor status.
[PMID 19094228] The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
[PMID 19304784] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
[PMID 19454617] Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.
[PMID 19528667] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
[PMID 19567422] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 20133699] Long-range enhancers on 8q24 regulate c-Myc.
[PMID 20146796] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
[PMID 20237344] Performance of common genetic variants in breast-cancer risk models.
[PMID 20484103] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
[PMID 20605201] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
[PMID 21596841] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
[PMID 22045194] Combined effect of low-penetrant SNPs on breast cancer risk.
[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.
[PMID 22532573] The role of genetic breast cancer susceptibility variants as prognostic factors.
[PMID 23565189] Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases
[PMID 23717390] Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm
[PMID 24171766] Common low-penetrance risk variants associated with breast cancer in Polish women
| GWAS snp | |
|---|---|
| PMID | [PMID 23535729]
|
| Trait | Breast cancer |
| Title | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. |
| Risk Allele | G |
| P-val | 1E-27 |
| Odds Ratio | 1.09 [1.07-1.12] |
[PMID 22910930] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
[PMID 22965832] Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.
[PMID 23292077] Association of 8q24 rs13281615A > G polymorphism with breast cancer risk: evidence from 40,762 cases and 50,380 controls.
[PMID 23577780] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
[PMID 24780616] Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer
[PMID 24532140] Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population
[PMID 28757652] Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study.
