rs13361189
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.6 | 2.6x increased risk for Crohn's disease |
| (C;T) | 1.3 | 1.3x increased risk for Crohn's disease |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 150843825 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs13361189 |
| dbSNP (classic) | rs13361189 |
| ClinGen | rs13361189 |
| ebi | rs13361189 |
| HLI | rs13361189 |
| Exac | rs13361189 |
| Gnomad | rs13361189 |
| Varsome | rs13361189 |
| LitVar | rs13361189 |
| Map | rs13361189 |
| PheGenI | rs13361189 |
| Biobank | rs13361189 |
| 1000 genomes | rs13361189 |
| hgdp | rs13361189 |
| ensembl | rs13361189 |
| geneview | rs13361189 |
| scholar | rs13361189 |
| rs13361189 | |
| pharmgkb | rs13361189 |
| gwascentral | rs13361189 |
| openSNP | rs13361189 |
| 23andMe | rs13361189 |
| SNPshot | rs13361189 |
| SNPdbe | rs13361189 |
| MSV3d | rs13361189 |
| GWAS Ctlg | rs13361189 |
| GMAF | 0.2746 |
| Max Magnitude | 2.6 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs13361189 is a SNP in the IRGM gene.
A study including 557 Crohn's disease (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that rs13361189(C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).[PMID 19491842]
23andMe blog Each copy of a C at rs13361189 increases a person's risk of developing Crohn's disease 1.33 times compared to someone with two copies of a T
| GWAS | |
|---|---|
| SNP | rs13361189 |
| PubMedID | [PMID 17554261 ]
|
| Condition | Crohn's disease |
| Gene | IRGM |
| Risk Allele | |
| pValue | 2.00E-010 |
| OR | 1.38 |
| 95% CI | 1.15-1.66 |
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 22713085] IRGM gene polymorphisms and risk of gastric cancer
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18580884] Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 19165925] Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
[PMID 19750224] Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
[PMID 20106866] Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
[PMID 20395867] Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
[PMID 21049557] NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
[PMID 24232856] Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis
[PMID 24264476] Autophagy Gene Polymorphism is Associated with Susceptibility to Leprosy by Affecting Inflammatory Cytokines
[PMID 22573572] Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
[PMID 24859836] Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions
[PMID 25009628] IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis
[PMID 26066377] Autophagy and inflammatory bowel disease: Association between variants of the autophagy-related IRGM gene and susceptibility to Crohn's disease
[PMID 29228965] Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.
[PMID 30335469] Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.
[PMID 31714311] Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn Disease.
