rs1344706
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | normal |
| (G;T) | 1.1 | 1.1x increased risk for schizophrenia |
| (T;T) | 1.2 | 1.2x increased risk for schizophrenia |
| Reference | GRCh38 38.1/142 |
| Chromosome | 2 |
| Position | 184913701 |
| Gene | ZNF804A |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1344706 |
| dbSNP (classic) | rs1344706 |
| ClinGen | rs1344706 |
| ebi | rs1344706 |
| HLI | rs1344706 |
| Exac | rs1344706 |
| Gnomad | rs1344706 |
| Varsome | rs1344706 |
| LitVar | rs1344706 |
| Map | rs1344706 |
| PheGenI | rs1344706 |
| Biobank | rs1344706 |
| 1000 genomes | rs1344706 |
| hgdp | rs1344706 |
| ensembl | rs1344706 |
| geneview | rs1344706 |
| scholar | rs1344706 |
| rs1344706 | |
| pharmgkb | rs1344706 |
| gwascentral | rs1344706 |
| openSNP | rs1344706 |
| 23andMe | rs1344706 |
| SNPshot | rs1344706 |
| SNPdbe | rs1344706 |
| MSV3d | rs1344706 |
| GWAS Ctlg | rs1344706 |
| GMAF | 0.3453 |
| Max Magnitude | 1.2 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1344706 is a SNP in the ZNF804A gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis.
[PMID 20688871
] Reviews the literature, and concludes that rs1344706 is "robustly, if modestly" associated with increased risk for schizophrenia.
[PMID 18677311] A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A (rs1344706; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included bipolar disorder (p = 9.96 x 10e-9).
| GWAS | |
|---|---|
| SNP | rs1344706 |
| PubMedID | [PMID 18677311] |
| Condition | Schizophrenia |
| Gene | ZNF804A |
| Risk Allele | T |
| pValue | 2.00E-007 |
| OR | 1.12 |
| 95% CI | |
[PMID 19407193] Neural mechanisms of a genome-wide supported psychosis variant
[PMID 19844207] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
[PMID 20603450] Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia
[PMID 20664580] A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes
[PMID 20688871] The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
[PMID 20946959] Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
[PMID 21234901] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population
[PMID 21525856] The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses
[PMID 21890790] Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia
[PMID 21276201] Bipolar disorder risk alleles in adult ADHD patients
[PMID 21988329] A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Screening ZNF804A Gene Polymorphism (rs1344706) in Patients with Schizophrenia: A Significant Association
[PMID 21993378] Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis
[PMID 22042765] Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity
[PMID 22373944] Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients
[PMID 19693005] Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
[PMID 19721717] Apoptotic engulfment pathway and schizophrenia.
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 20048749] Expanding the range of ZNF804A variants conferring risk of psychosis.
[PMID 20231838] Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task.
[PMID 20368704] Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
[PMID 20485477] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
[PMID 20934520] ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.
[PMID 20957649] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.
[PMID 21040459] ZNF804A may be associated with executive control of attention.
[PMID 21302348] Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population.
[PMID 21349497] Evidence of sex-modulated association of ZNF804A with schizophrenia.
[PMID 21457757] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.
[PMID 21767209] ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.
[PMID 21810628] Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.
[PMID 21892778] The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.
[PMID 21911029] Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.
[PMID 22328493] Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia.
[PMID 22384243] ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
[PMID 22416237] The effects of psychosis risk variants on brain connectivity: a review.
[PMID 22425527] Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.
[PMID 23212061] Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development
[PMID 23351715] Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder
[PMID 23562677] ZNF804A and cortical thickness in schizophrenia and bipolar disorder
[PMID 24066410] Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients
[PMID 24247043] Further Evidence for The Impact of a Genome-Wide Supported Psychosis Risk Variant in ZNF804A on The Theory of Mind Network
[PMID 24315717] Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex
[PMID 24424391] Effects of ZNF804A on auditory P300 response in schizophrenia
[PMID 24462263] Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 22775511] ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca.
[PMID 22781169] Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling.
[PMID 22840435] An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain.
[PMID 22871346] Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.
[PMID 22887939] ZNF804A and schizophrenia susceptibility in Asian populations.
[PMID 23147122] No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.
[PMID 23295962] ZNF804A genotype modulates neural activity during working memory for faces.
[PMID 23590871] Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.
[PMID 25162540] Expression of ZNF804A in Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Novel Transcript Fetally Regulated by the Psychosis Risk Variant rs1344706
[PMID 25757652] Modulation of hippocampal theta and hippocampal-prefrontal cortex function by a schizophrenia risk gene
[PMID 25921517] ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls
[PMID 26382569] Replication of ZNF804A gene variant associations with risk of heroin addiction
[PMID 26654932] Effect of rs1344706 in the ZNF804A gene on the connectivity between the hippocampal formation and posterior cingulate cortex.
[PMID 26866941] A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations.
[PMID 26934312] No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese.
[PMID 26966642] Genome-wide discovered psychosis-risk gene ZNF804A impacts on white matter microstructure in health, schizophrenia and bipolar disorder.
[PMID 27790829] The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder.
[PMID 28289284] The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions.
[PMID 28883732] Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach.
[PMID 29527501] Effect of rs1344706 in the ZNF804A gene on the brain network.
[PMID 31122238] Family-based association study of ZNF804A polymorphisms and autism in a Han Chinese population.
