rs135745
| Orientation | plus |
| Stabilized | plus |
| Make rs135745(C;C) |
| Make rs135745(C;G) |
| Make rs135745(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 22 |
| Position | 38287631 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs135745 |
| dbSNP (classic) | rs135745 |
| ClinGen | rs135745 |
| ebi | rs135745 |
| HLI | rs135745 |
| Exac | rs135745 |
| Gnomad | rs135745 |
| Varsome | rs135745 |
| LitVar | rs135745 |
| Map | rs135745 |
| PheGenI | rs135745 |
| Biobank | rs135745 |
| 1000 genomes | rs135745 |
| hgdp | rs135745 |
| ensembl | rs135745 |
| geneview | rs135745 |
| scholar | rs135745 |
| rs135745 | |
| pharmgkb | rs135745 |
| gwascentral | rs135745 |
| openSNP | rs135745 |
| 23andMe | rs135745 |
| SNPshot | rs135745 |
| SNPdbe | rs135745 |
| MSV3d | rs135745 |
| GWAS Ctlg | rs135745 |
| GMAF | 0.4132 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
This SNP, located in the 3' UTR of the CSNK1E gene, has been associated with sensitivity to the acute effects of d-amphetamine. Sensitivity to psychoactive drugs has been associated with potential to develop drug abuse. The more sensitive allele is rs135745(C). [PMID 16237383]
However, in a separate study, this SNP did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population.[PMID 18991847]
Note: orientation relative to dbSNP needs to be confirmed/checked.
[PMID 18518925
] Genetic susceptibility to heroin addiction: a candidate gene association study.
[PMID 19050854] A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.
[PMID 20174623] Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
[PMID 22367616] Association between a casein kinase 1 epsilon gene polymorphism and schizophrenia in a Chinese Han population.
[PMID 22113361] No association of a casein kinase 1epsilon (CK1epsilon) gene polymorphism with personality traits in healthy Chinese-Han subjects.
