rs1360780
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 2 | 1.3x increased risk for depression |
| (T;T) | 2.1 | 1.3x increased risk for depression |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 35639794 |
| Gene | FKBP5 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1360780 |
| dbSNP (classic) | rs1360780 |
| ClinGen | rs1360780 |
| ebi | rs1360780 |
| HLI | rs1360780 |
| Exac | rs1360780 |
| Gnomad | rs1360780 |
| Varsome | rs1360780 |
| LitVar | rs1360780 |
| Map | rs1360780 |
| PheGenI | rs1360780 |
| Biobank | rs1360780 |
| 1000 genomes | rs1360780 |
| hgdp | rs1360780 |
| ensembl | rs1360780 |
| geneview | rs1360780 |
| scholar | rs1360780 |
| rs1360780 | |
| pharmgkb | rs1360780 |
| gwascentral | rs1360780 |
| openSNP | rs1360780 |
| 23andMe | rs1360780 |
| SNPshot | rs1360780 |
| SNPdbe | rs1360780 |
| MSV3d | rs1360780 |
| GWAS Ctlg | rs1360780 |
| GMAF | 0.2994 |
| Max Magnitude | 2.1 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
In Caucasian non-Hispanics, the rs1360780(T) allele is associated with increased risk for depression, with an odds ratio of 1.39 (CI: 1.14-1.70, p=0.046).[PMID 18191112
]
This same SNP, which is in the FKBP5 gene, may influence how patients respond to antidepressants including citalopram. rs1360780(T;T) homozgyotes tend to report more depressive episodes, but they also respond better to treatment with antidepressants.[PMID 15565110]
[PMID 18349090] rs9296158 rs3800373 rs1360780 rs9470080 linked with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing.
[PMID 19924111] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
[PMID 20090668] Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
[PMID 19233472] Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection
[PMID 20008943] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study
[PMID 20393453] Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder
[PMID 20547006] FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction
[PMID 20709156] Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders
[PMID 21654733] Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population
[PMID 22134958] Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients
[PMID 21788965] Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms.
[PMID 22825419] FK506-binding protein 51 (FKBP5) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura
[PMID 15637659] Linkage disequilibrium patterns and tagSNP transferability among European populations.
[PMID 17081296] Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.
[PMID 18702710] Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.
[PMID 18803430] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
[PMID 19199039] Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder.
[PMID 19455174] Psychobiology and molecular genetics of resilience.
[PMID 19676097] FKBP5 polymorphisms and antidepressant response in geriatric depression.
[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
[PMID 20726698] Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.
[PMID 20849924] Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects.
[PMID 21112363] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21316860] Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach.
[PMID 21449676] Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.
[PMID 22213790] Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.
[PMID 22979952] FKBP5 AND EMOTIONAL NEGLECT INTERACT TO PREDICT INDIVIDUAL DIFFERENCES IN AMYGDALA REACTIVITY
[PMID 22781842] Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
[PMID 24253961] FKBP5 Genotype and Structural Integrity of the Posterior Cingulum
[PMID 22459275] FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: a controlled and prospective study.
[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
[PMID 24766650] Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans
[PMID 24845178] Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype
[PMID 24856550] FKBP5 polymorphism is associated with major depression but not with bipolar disorder
[PMID 25088286] Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population
[PMID 25115650] Placental FKBP5 Genetic and Epigenetic Variation Is Associated with Infant Neurobehavioral Outcomes in the RICHS Cohort
[PMID 27078785] FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study
[PMID 27648526] The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure.
[PMID 28889074] Interaction between FKBP5 gene and childhood trauma on psychosis, depression and anxiety symptoms in a non-clinical sample.
[PMID 29576410] The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans.
[PMID 30619472] Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA.
[PMID 30678080] FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression.
[PMID 31291236] A Candidate Gene Association Study of FKBP5 and CRHR1 Polymorphisms in Relation to War-Related Posttraumatic Stress Disorder.
[PMID 31465499] rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents.
[PMID 31510784] FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.
[PMID 31927265] Genetic association of FKBP5 with PTSD in US service members deployed to Iraq and Afghanistan.
[PMID 32553385] Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder.
[PMID 32860562] Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study.
[PMID 32957930] Genetic risk-factors for anxiety in healthy individuals: polymorphisms in genes important for the HPA axis.
[PMID 33030232] FKBP5 Polymorphisms Induce Differential Glucocorticoid Responsiveness in Primary CNS Cells - First Insights from Novel Humanized Mice.
