rs1387153
| Orientation | plus |
| Stabilized | plus |
| Make rs1387153(C;C) |
| Make rs1387153(C;T) |
| Make rs1387153(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 92940662 |
| Gene | MIR194-2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1387153 |
| dbSNP (classic) | rs1387153 |
| ClinGen | rs1387153 |
| ebi | rs1387153 |
| HLI | rs1387153 |
| Exac | rs1387153 |
| Gnomad | rs1387153 |
| Varsome | rs1387153 |
| LitVar | rs1387153 |
| Map | rs1387153 |
| PheGenI | rs1387153 |
| Biobank | rs1387153 |
| 1000 genomes | rs1387153 |
| hgdp | rs1387153 |
| ensembl | rs1387153 |
| geneview | rs1387153 |
| scholar | rs1387153 |
| rs1387153 | |
| pharmgkb | rs1387153 |
| gwascentral | rs1387153 |
| openSNP | rs1387153 |
| 23andMe | rs1387153 |
| SNPshot | rs1387153 |
| SNPdbe | rs1387153 |
| MSV3d | rs1387153 |
| GWAS Ctlg | rs1387153 |
| GMAF | 0.3466 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19060909] |
| Trait | Fasting plasma glucose |
| Title | A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk |
| Risk Allele | T |
| P-val | 2E-36 |
| Odds Ratio | 0.07 [0.05-0.08] mmol/l increase |
[PMID 19651812
] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
[PMID 20536959] Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
| GWAS snp | |
|---|---|
| PMID | [PMID 20581827]
|
| Trait | Type 2 diabetes |
| Title | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis |
| Risk Allele | T |
| P-val | 8E-15 |
| Odds Ratio | 1.09 [1.06-1.11] |
[PMID 20858683] Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
| GWAS snp | |
|---|---|
| PMID | [PMID 21386085]
|
| Trait | |
| Title | A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium |
| Risk Allele | C |
| P-val | 2E-9 |
| Odds Ratio | 0.2100 [0.15-0.27] unit decrease |
[PMID 21658282] Melatonin Receptor 1 B Polymorphisms associated with the risk of Gestational Diabetes Mellitus
[PMID 22450346] The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
[PMID 22768333] Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women
[PMID 19060907] Variants in MTNR1B influence fasting glucose levels.
[PMID 19324940] G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
[PMID 20628598] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21445555] Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
[PMID 21558052] A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.
[PMID 23690305] Genetic variants and the risk of gestational diabetes mellitus: a systematic review
[PMID 23560644] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.
[PMID 26563312] Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis
[PMID 29871606] Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population.
[PMID 32656703] MTNR1B gene on susceptibility to gestational diabetes mellitus: a two-stage hospital-based study in Southern China.
