rs1414334
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | associated with metabolic syndrome when taking antipsychotics |
| Make rs1414334(C;G) |
| Make rs1414334(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | X |
| Position | 114903581 |
| Gene | HTR2C |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1414334 |
| dbSNP (classic) | rs1414334 |
| ClinGen | rs1414334 |
| ebi | rs1414334 |
| HLI | rs1414334 |
| Exac | rs1414334 |
| Gnomad | rs1414334 |
| Varsome | rs1414334 |
| LitVar | rs1414334 |
| Map | rs1414334 |
| PheGenI | rs1414334 |
| Biobank | rs1414334 |
| 1000 genomes | rs1414334 |
| hgdp | rs1414334 |
| ensembl | rs1414334 |
| geneview | rs1414334 |
| scholar | rs1414334 |
| rs1414334 | |
| pharmgkb | rs1414334 |
| gwascentral | rs1414334 |
| openSNP | rs1414334 |
| 23andMe | rs1414334 |
| SNPshot | rs1414334 |
| SNPdbe | rs1414334 |
| MSV3d | rs1414334 |
| GWAS Ctlg | rs1414334 |
| GMAF | 0.1856 |
| Max Magnitude | 2 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 19142101] rs1414334(C) associated with the metabolic syndrome in patients using
- clozapine (OR, 9.20; 95% CI, 1.95-43.45)
- risperidone (OR, 5.35; 95% CI, 1.26-22.83)
[PMID 20680028] Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study
[PMID 21186965
] Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene
[PMID 21105285] Combined HTR2C-LEP genotype as a determinant of obesity in patients using antipsychotic medication
[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.
[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.
| ClinVar | |
|---|---|
| Risk | rs1414334(G;G) |
| Alt | rs1414334(G;G) |
| Reference | Rs1414334(C;C) |
| Significance | Drug-response |
| Disease | Risperidone response - Toxicity/ADR antipsychotics response - Toxicity/ADR clozapine response - Toxicity/ADR |
| Variation | info |
| Gene | HTR2C |
| CLNDBN | risperidone response - Toxicity/ADR antipsychotics response - Toxicity/ADR clozapine response - Toxicity/ADR |
| Reversed | 0 |
| HGVS | NC_000023.10:g.114138144C>G |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211204.1, RCV000211340.1, RCV000211420.1, |
