rs143332484

plus

Geno	Mag	Summary
(C;T)	2	Moderate increase (1.67x) in risk for Alzheimer's disease
(T;T)	2	Moderate increase (1.67x) in risk for Alzheimer's disease

Reference

GRCh38.p7 38.3/150

Chromosome

6

Position

41161469

Gene	LOC105375056, TREM2

is a	snp
is	mentioned by
dbSNP	rs143332484
dbSNP (classic)	rs143332484
ClinGen	rs143332484
ebi	rs143332484
HLI	rs143332484
Exac	rs143332484
Gnomad	rs143332484
Varsome	rs143332484
LitVar	rs143332484
Map	rs143332484
PheGenI	rs143332484
Biobank	rs143332484
1000 genomes	rs143332484
hgdp	rs143332484
ensembl	rs143332484
geneview	rs143332484
scholar	rs143332484
google	rs143332484
pharmgkb	rs143332484
gwascentral	rs143332484
openSNP	rs143332484
23andMe	rs143332484
SNPshot	rs143332484
SNPdbe	rs143332484
MSV3d	rs143332484
GWAS Ctlg	rs143332484

Max Magnitude

2

rs143332484 (p.Arg62His) is a risk variant for Alzheimer's disease found in the TREM2 gene (P = 1.55 × 10-14, OR = 1.67). This gene is highly expressed in microglia which are known to interact with the immune system in AD.[PMID 28714976 ]