rs144475004
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 3.5 | Significant (6x) increase in risk for psoriasis, at least in Asians |
| (C;G) | 3.5 | Signficant (6x) increase in risk for psoriasis, at least in Asians |
| (G;G) | 0 | common/normal |
| Reference | GRCh38.p2 38.2/147 |
| Chromosome | 17 |
| Position | 80184089 |
| Gene | CARD14 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs144475004 |
| dbSNP (classic) | rs144475004 |
| ClinGen | rs144475004 |
| ebi | rs144475004 |
| HLI | rs144475004 |
| Exac | rs144475004 |
| Gnomad | rs144475004 |
| Varsome | rs144475004 |
| LitVar | rs144475004 |
| Map | rs144475004 |
| PheGenI | rs144475004 |
| Biobank | rs144475004 |
| 1000 genomes | rs144475004 |
| hgdp | rs144475004 |
| ensembl | rs144475004 |
| geneview | rs144475004 |
| scholar | rs144475004 |
| rs144475004 | |
| pharmgkb | rs144475004 |
| gwascentral | rs144475004 |
| openSNP | rs144475004 |
| 23andMe | rs144475004 |
| SNPshot | rs144475004 |
| SNPdbe | rs144475004 |
| MSV3d | rs144475004 |
| GWAS Ctlg | rs144475004 |
| Max Magnitude | 3.5 |
rs144475004, also known as c.526G>C, p.Asp176His and D176H, represents a variant in the CARD14 gene on chromosome 17.
In 416 psoriasis patients, the rs144475004(C) allele was associated in Asian individuals with generalized pustular psoriasis (odds ratio 6.4, p=8.4×10e-5), but no CARD14 mutations were found to be associated with other forms of psoriasis vulgaris (PV) or with pityriasis rubra pilaris (PRP).[PMID 26203641]
