rs147210663

plus

Geno	Mag	Summary
(A;G)	4	rare variant with large positive effect
(G;G)	0	common in ClinVar

Make rs147210663(A;A)

Reference

GRCh38 38.1/141

Chromosome

11

Position

116830844

Gene

APOC3

is a	snp
is	mentioned by
dbSNP	rs147210663
dbSNP (classic)	rs147210663
ClinGen	rs147210663
ebi	rs147210663
HLI	rs147210663
Exac	rs147210663
Gnomad	rs147210663
Varsome	rs147210663
LitVar	rs147210663
Map	rs147210663
PheGenI	rs147210663
Biobank	rs147210663
1000 genomes	rs147210663
hgdp	rs147210663
ensembl	rs147210663
geneview	rs147210663
scholar	rs147210663
google	rs147210663
pharmgkb	rs147210663
gwascentral	rs147210663
openSNP	rs147210663
23andMe	rs147210663
SNPshot	rs147210663
SNPdbe	rs147210663
MSV3d	rs147210663
GWAS Ctlg	rs147210663

Max Magnitude

4

rs147210663, also known as A43T, is a rare variant in the apolipoprotein C3 APOC3 gene.

As reported in two large studies published in 2014, rs147210663 is one of several loss of function mutations in the APOC3 gene associated with a >40% lower average triglyceride level in individuals carrying one rs147210663(A) allele and a corresponding decrease in coronary artery disease.[PMID 24941081 ][PMID 24941082]

ClinVar
Risk	rs147210663(A;A) rs147210663(T;T)
Alt	rs147210663(A;A) rs147210663(T;T)
Reference	Rs147210663(G;G)
Significance	Other
Disease	Coronary heart disease Hyperalphalipoproteinemia 2
Variation	info
Gene	APOC3
CLNDBN	Coronary heart disease Hyperalphalipoproteinemia 2
Reversed	0
HGVS	NC_000011.9:g.116701560G>A
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000128450.1, RCV000148019.3,