rs1495741

plus

Geno	Mag	Summary
(A;A)	2	NAT2 slow metabolizer (predicted)
(A;G)	2	NAT2 intermediate metabolizer (predicted)
(G;G)	2	NAT2 rapid metabolizer (predicted)

Reference

GRCh38 38.1/141

Chromosome

8

Position

18415371

is a	snp
is	mentioned by
dbSNP	rs1495741
dbSNP (classic)	rs1495741
ClinGen	rs1495741
ebi	rs1495741
HLI	rs1495741
Exac	rs1495741
Gnomad	rs1495741
Varsome	rs1495741
LitVar	rs1495741
Map	rs1495741
PheGenI	rs1495741
Biobank	rs1495741
1000 genomes	rs1495741
hgdp	rs1495741
ensembl	rs1495741
geneview	rs1495741
scholar	rs1495741
google	rs1495741
pharmgkb	rs1495741
gwascentral	rs1495741
openSNP	rs1495741
23andMe	rs1495741
SNPshot	rs1495741
SNPdbe	rs1495741
MSV3d	rs1495741
GWAS Ctlg	rs1495741

GMAF

0.3774

Max Magnitude

2

With 99% sensitivity and 95% specificity, at least in Caucasian populations, rs1495741 is reported to classify the NAT2 phenotype of an individual; it therefore is a candidate to replace the 7-SNP panel used in genosets such as gs138, gs139, and gs140. The rs1495741(A;A), (A;G) and (G;G) genotypes predicted slow, intermediate, and rapid NAT2 acetylation phenotypes, respectively.[PMID 20739907 ]

?

(A;A) (A;G) (G;G)

28

GWAS snp
PMID	[PMID 20972438 ]
Trait
Title	A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Risk Allele
P-val	4E-11
Odds Ratio	1.1500 [1.10-1.20]

[PMID 21750470] Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype

[PMID 22092036 ] Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes

GWAS snp
PMID	[PMID 20686565 ]
Trait
Title	Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele	G
P-val	4E-14
Odds Ratio	2.9700 None

[PMID 22686316] Polymorphic enzymes, urinary bladder cancer risk, and structural change in the local industry

[PMID 22336957] Impact of population diversity on the prediction of 7-SNP NAT2 phenotypes using the tagSNP rs1495741 or paired SNPs.

[PMID 22414877 ] Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples.

[PMID 24524665] Improvements in Algorithms for Phenotype Inference: The NAT2 Example

[PMID 23133420 ] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

[PMID 23407048] The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity.

GWAS snp
PMID	[PMID 24163127 ]
Trait	Bladder cancer
Title	Genome-wide association study identifies multiple loci associated with bladder cancer risk.
Risk Allele	A
P-val	2E-10
Odds Ratio	1.14 [1.09-1.18]

GWAS snp
PMID	[PMID 24097068 ]
Trait	Cholesterol, total
Title	Discovery and refinement of loci associated with lipid levels.
Risk Allele	G
P-val	3E-8
Odds Ratio	.03 [NR] unit increase

GWAS snp
PMID	[PMID 24816252 ]
Trait	Blood metabolite levels
Title	An atlas of genetic influences on human blood metabolites.
Risk Allele	A
P-val	1E-27
Odds Ratio	.06 [0.047-0.067] unit increase

[PMID 25794903] Determination of NAT2 acetylation status in the Greenlandic population

[PMID 31066138] Relevance of NAT2 genotype to anti-tuberculosis drug-induced hepatotoxicity in a Chinese Han population.

[PMID 31109976 ] Genome-Wide Association Study Confirming the Association of NAT2 with Susceptibility to Anti-tuberculosis Drug-Induced Liver Injury in Thai Patients.