rs1517114

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	0	common in clinvar

Make rs1517114(C;G)

Make rs1517114(G;G)

Reference

GRCh38 38.1/141

Chromosome

8

Position

68476982

Gene

C8orf34

is a	snp
is	mentioned by
dbSNP	rs1517114
dbSNP (classic)	rs1517114
ClinGen	rs1517114
ebi	rs1517114
HLI	rs1517114
Exac	rs1517114
Gnomad	rs1517114
Varsome	rs1517114
LitVar	rs1517114
Map	rs1517114
PheGenI	rs1517114
Biobank	rs1517114
1000 genomes	rs1517114
hgdp	rs1517114
ensembl	rs1517114
geneview	rs1517114
scholar	rs1517114
google	rs1517114
pharmgkb	rs1517114
gwascentral	rs1517114
openSNP	rs1517114
23andMe	rs1517114
SNPshot	rs1517114
SNPdbe	rs1517114
MSV3d	rs1517114
GWAS Ctlg	rs1517114

GMAF

0.314

Max Magnitude

0

?	(C;C) (C;G) (G;G)	28

GWAS snp
PMID	[PMID 22664479]
Trait
Title	A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer.
Risk Allele	C
P-val	0.000009
Odds Ratio	4.1000 None

ClinVar
Risk	rs1517114(G;G) rs1517114(T;T)
Alt	rs1517114(G;G) rs1517114(T;T)
Reference	Rs1517114(C;C)
Significance	Drug-response
Disease	irinotecan response - Toxicity/ADR
Variation	info
Gene	C8orf34
CLNDBN	irinotecan response - Toxicity/ADR
Reversed	0
HGVS	NC_000008.10:g.69389217C>G
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000211148.1,