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From SNPedia

Geno Mag Summary
(A;A) Higher BMI than normal
(A;T) Higher BMI than normal
(T;T) Normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1558902
1000 genomesrs1558902
GWAS Ctlgrs1558902
Max Magnitude0
? (A;A) (A;T) (T;T) 28

GWAS snp
PMID [PMID 19557197OA-icon.png]
Trait Waist circumference
Title NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
Risk Allele
P-val 5E-19
Odds Ratio NR NR

[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese

GWAS snp
PMID [PMID 20421936OA-icon.png]
Trait Obesity (extreme)
Title Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups
Risk Allele A
P-val 7E-13
Odds Ratio 1.37 [1.26-1.50]
GWAS snp
PMID [PMID 20935630OA-icon.png]
Title Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Risk Allele A
P-val 5E-120
Odds Ratio 0.39 [0.35-0.43] kg/m2 increase

[PMID 21443588] Association between the FTO gene and overweight in Japanese children and adolescents

GWAS snp
PMID [PMID 21544081]
Title Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
Risk Allele T
P-val 1E-7
Odds Ratio 0.0900 [0.06-0.12] unit decrease

[PMID 21796137] Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population

[PMID 22235250OA-icon.png] Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height

[PMID 22589738OA-icon.png] Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women

[PMID 18379722OA-icon.png] Variations in the FTO gene are associated with severe obesity in the Japanese.

[PMID 20703240] Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.

[PMID 22041983] Recapitulation of genome-wide association studies on body mass index in the Korean population.

[PMID 22222230] FTO gene polymorphisms and platelet counts in a general Japanese population.

[PMID 22504289] FTO, Abdominal Adiposity, Fasting Hyperglycemia Associated with Elevated HbA1c in Japanese Middle-Aged Women.

[PMID 23254338] FTO First Intron rs1558902 Variant and Platelets Count in White Middle-aged Women: Prague Pre and Post Menopausal Females (3PMFs) Study

[PMID 24084939OA-icon.png] A common biological basis of obesity and nicotine addiction

[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility

GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Obesity
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele A
P-val 2E-81
Odds Ratio 1.14 [NR]

[PMID 22891219OA-icon.png] FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.

[PMID 23471855OA-icon.png] The genetics of childhood obesity and interaction with dietary macronutrients.

[PMID 24911064OA-icon.png] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents

[PMID 24983943OA-icon.png] Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study

[PMID 25091360] Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years

GWAS snp
PMID [PMID 24861553OA-icon.png]
Trait Body mass index
Title Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Risk Allele A
P-val 7E-27
Odds Ratio .08 [0.062-0.089] unit increase

[PMID 25761503OA-icon.png] Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity

[PMID 27820839OA-icon.png] FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.

[PMID 28528403OA-icon.png] Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.

[PMID 29212175OA-icon.png] The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study.

[PMID 29548861] Familial aggregation and linkage analysis with covariates for metabolic syndrome risk factors.

[PMID 32384785OA-icon.png] Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma.