rs1558902
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | Higher BMI than normal | |
| (A;T) | Higher BMI than normal | |
| (T;T) | Normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 53769662 |
| Gene | FTO |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1558902 |
| dbSNP (classic) | rs1558902 |
| ClinGen | rs1558902 |
| ebi | rs1558902 |
| HLI | rs1558902 |
| Exac | rs1558902 |
| Gnomad | rs1558902 |
| Varsome | rs1558902 |
| LitVar | rs1558902 |
| Map | rs1558902 |
| PheGenI | rs1558902 |
| Biobank | rs1558902 |
| 1000 genomes | rs1558902 |
| hgdp | rs1558902 |
| ensembl | rs1558902 |
| geneview | rs1558902 |
| scholar | rs1558902 |
| rs1558902 | |
| pharmgkb | rs1558902 |
| gwascentral | rs1558902 |
| openSNP | rs1558902 |
| 23andMe | rs1558902 |
| SNPshot | rs1558902 |
| SNPdbe | rs1558902 |
| MSV3d | rs1558902 |
| GWAS Ctlg | rs1558902 |
| GMAF | 0.2479 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19557197 ]
|
| Trait | Waist circumference |
| Title | NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium |
| Risk Allele | |
| P-val | 5E-19 |
| Odds Ratio | NR NR |
[PMID 20075932] Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
| GWAS snp | |
|---|---|
| PMID | [PMID 20421936]
|
| Trait | Obesity (extreme) |
| Title | Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups |
| Risk Allele | A |
| P-val | 7E-13 |
| Odds Ratio | 1.37 [1.26-1.50] |
| GWAS snp | |
|---|---|
| PMID | [PMID 20935630]
|
| Trait | |
| Title | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index |
| Risk Allele | A |
| P-val | 5E-120 |
| Odds Ratio | 0.39 [0.35-0.43] kg/m2 increase |
[PMID 21443588] Association between the FTO gene and overweight in Japanese children and adolescents
| GWAS snp | |
|---|---|
| PMID | [PMID 21544081] |
| Trait | |
| Title | Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. |
| Risk Allele | T |
| P-val | 1E-7 |
| Odds Ratio | 0.0900 [0.06-0.12] unit decrease |
[PMID 21796137] Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
[PMID 22235250] Quantile-specific penetrance of genes affecting lipoproteins, adiposity and height
[PMID 22589738] Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
[PMID 18379722] Variations in the FTO gene are associated with severe obesity in the Japanese.
[PMID 20703240] Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population.
[PMID 22041983] Recapitulation of genome-wide association studies on body mass index in the Korean population.
[PMID 22222230] FTO gene polymorphisms and platelet counts in a general Japanese population.
[PMID 22504289] FTO, Abdominal Adiposity, Fasting Hyperglycemia Associated with Elevated HbA1c in Japanese Middle-Aged Women.
[PMID 23254338] FTO First Intron rs1558902 Variant and Platelets Count in White Middle-aged Women: Prague Pre and Post Menopausal Females (3PMFs) Study
[PMID 24084939] A common biological basis of obesity and nicotine addiction
[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility
| GWAS snp | |
|---|---|
| PMID | [PMID 23563607]
|
| Trait | Obesity |
| Title | Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. |
| Risk Allele | A |
| P-val | 2E-81 |
| Odds Ratio | 1.14 [NR] |
[PMID 22891219] FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial.
[PMID 23471855] The genetics of childhood obesity and interaction with dietary macronutrients.
[PMID 24911064] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
[PMID 24983943] Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study
[PMID 25091360] Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years
| GWAS snp | |
|---|---|
| PMID | [PMID 24861553]
|
| Trait | Body mass index |
| Title | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. |
| Risk Allele | A |
| P-val | 7E-27 |
| Odds Ratio | .08 [0.062-0.089] unit increase |
[PMID 25761503] Dietary Fat Modifies the Effects of FTO Genotype on Changes in Insulin Sensitivity
[PMID 27820839] FTO Gene Polymorphism Is Associated with Type 2 Diabetes through Its Effect on Increasing the Maximum BMI in Japanese Men.
[PMID 28528403] Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.
[PMID 29212175] The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study.
[PMID 29548861] Familial aggregation and linkage analysis with covariates for metabolic syndrome risk factors.
[PMID 32384785] Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma.
