rs157580
| Orientation | plus |
| Stabilized | plus |
| Make rs157580(A;A) |
| Make rs157580(A;G) |
| Make rs157580(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 44892009 |
| Gene | TOMM40 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs157580 |
| dbSNP (classic) | rs157580 |
| ClinGen | rs157580 |
| ebi | rs157580 |
| HLI | rs157580 |
| Exac | rs157580 |
| Gnomad | rs157580 |
| Varsome | rs157580 |
| LitVar | rs157580 |
| Map | rs157580 |
| PheGenI | rs157580 |
| Biobank | rs157580 |
| 1000 genomes | rs157580 |
| hgdp | rs157580 |
| ensembl | rs157580 |
| geneview | rs157580 |
| scholar | rs157580 |
| rs157580 | |
| pharmgkb | rs157580 |
| gwascentral | rs157580 |
| openSNP | rs157580 |
| 23andMe | rs157580 |
| SNPshot | rs157580 |
| SNPdbe | rs157580 |
| MSV3d | rs157580 |
| GWAS Ctlg | rs157580 |
| GMAF | 0.371 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19125160] |
| Trait | Alzheimer's disease |
| Title | Examination of the current top candidate genes for AD in a genome-wide association study |
| Risk Allele | |
| P-val | 1E-40 |
| Odds Ratio | NR NR |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060911 ]
|
| Trait | HDL cholesterol |
| Title | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts |
| Risk Allele | G |
| P-val | 4E-7 |
| Odds Ratio | 0.06 [NR] SD increase |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060910]
|
| Trait | LDL cholesterol |
| Title | Genome-wide association analysis of metabolic traits in a birth cohort from a founder population |
| Risk Allele | G |
| P-val | 5E-8 |
| Odds Ratio | 0.11 [0.07-0.15] mmol/l decrease |
The G allele of this SNP in the TOMM40 gene may be associated with late-onset Alzheimer's disease.
| GWAS snp | |
|---|---|
| PMID | [PMID 21123754]
|
| Trait | |
| Title | Genome-wide association study of CSF biomarkers A{beta}1-42, t-tau, and p-tau181p in the ADNI cohort. |
| Risk Allele | |
| P-val | 0.000001 |
| Odds Ratio | None None |
| GWAS snp | |
|---|---|
| PMID | [PMID 21627779]
|
| Trait | |
| Title | The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. |
| Risk Allele | |
| P-val | 8E-89 |
| Odds Ratio | 1.6900 [NR] |
[PMID 17658295] Association of ApoE genetic variants with obstructive sleep apnea in children.
[PMID 18439548] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
[PMID 18823527] A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
[PMID 19668339] Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
[PMID 19734902] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 20061627] Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
[PMID 20502693] Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
[PMID 21390209] Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.
[PMID 23435269] Chronic Family Stress Moderates the Association between a TOMM40 Variant and Triglyceride Levels in Two Independent Caucasian Samples
[PMID 23288655] Association of TOMM40 polymorphisms with late-onset Alzheimer's disease in a Northern Han Chinese population
[PMID 22430674] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
[PMID 23193196] Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.
[PMID 23546992] TOMM40 polymorphisms in Italian Alzheimer's disease and frontotemporal dementia patients.
[PMID 25711031] [TOMM40 gene polymorphism association with lipid profile]
[PMID 26252223] Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes
[PMID 26543236] Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population
[PMID 29670124] BCL3-PVRL2-TOMM40 SNPs, gene-gene and gene-environment interactions on dyslipidemia.
[PMID 30319691] Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
