rs1585215

minus

Geno	Mag	Summary
(A;A)	0	normal
(A;G)	2	2x increased risk for Hodgkin lymphoma
(G;G)	2.1	3.5x increased risk for Hodgkin lymphoma

Reference

GRCh38 38.1/141

Chromosome

4

Position

102523317

Gene

NFKB1

is a	snp
is	mentioned by
dbSNP	rs1585215
dbSNP (classic)	rs1585215
ClinGen	rs1585215
ebi	rs1585215
HLI	rs1585215
Exac	rs1585215
Gnomad	rs1585215
Varsome	rs1585215
LitVar	rs1585215
Map	rs1585215
PheGenI	rs1585215
Biobank	rs1585215
1000 genomes	rs1585215
hgdp	rs1585215
ensembl	rs1585215
geneview	rs1585215
scholar	rs1585215
google	rs1585215
pharmgkb	rs1585215
gwascentral	rs1585215
openSNP	rs1585215
23andMe	rs1585215
SNPshot	rs1585215
SNPdbe	rs1585215
MSV3d	rs1585215
GWAS Ctlg	rs1585215

GMAF

0.292

Max Magnitude

2.1

?

(A;A) (A;G) (G;G)

28

rs1585215 is a SNP in the NFKB1 gene.

A population-based case-control study including 473 cases of Hodgkin lymphoma concluded that increased risk for the disease was significantly associated with rs1585215. The odds ratio for rs1585215(G;G) homozygotes was 3.5 (CI: 2.2-5.7, Ptrend = 1.7 x 10(-8)), and for (A;G) heterozygotes, 2.1 (CI: 1.5-2.9).[PMID 19223558 ]

[PMID 25422198] Polymorphic variation of inflammation-related genes and risk of non-Hodgkin lymphoma for Uygur and Han Chinese in Xinjiang