rs16892766
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common in complete genomics |
| (A;C) | 2 | slight (~1.5x) increase in colorectal cancer risk |
| (C;C) | 2 | slight (~2x) increase in colorectal cancer risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 116618444 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs16892766 |
| dbSNP (classic) | rs16892766 |
| ClinGen | rs16892766 |
| ebi | rs16892766 |
| HLI | rs16892766 |
| Exac | rs16892766 |
| Gnomad | rs16892766 |
| Varsome | rs16892766 |
| LitVar | rs16892766 |
| Map | rs16892766 |
| PheGenI | rs16892766 |
| Biobank | rs16892766 |
| 1000 genomes | rs16892766 |
| hgdp | rs16892766 |
| ensembl | rs16892766 |
| geneview | rs16892766 |
| scholar | rs16892766 |
| rs16892766 | |
| pharmgkb | rs16892766 |
| gwascentral | rs16892766 |
| openSNP | rs16892766 |
| 23andMe | rs16892766 |
| SNPshot | rs16892766 |
| SNPdbe | rs16892766 |
| MSV3d | rs16892766 |
| GWAS Ctlg | rs16892766 |
| GMAF | 0.07208 |
| Max Magnitude | 2 |
10.1038/ejhg.2015.72 rs16892766 on 8q23.3 (colorectal cancer OR 1.88, CI: 1.30–2.72, P=0.0007)
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs16892766 |
| PubMedID | [PMID 18372905] |
| Condition | Colorectal cancer |
| Gene | EIF3H |
| Risk Allele | A |
| pValue | 3.00E-018 |
| OR | 1.27 |
| 95% CI | 1.20-1.34 |
[PMID 19843678] Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
[PMID 20638935] Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype
[PMID 21097774] Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome
[PMID 21119214
] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
| GWAS snp | |
|---|---|
| PMID | [PMID 21761138]
|
| Trait | |
| Title | Meta-analysis of new genome-wide association studies of colorectal cancer risk. |
| Risk Allele | |
| P-val | 4E-7 |
| Odds Ratio | 1.2400 [1.14-1.34] |
[PMID 22367214] Characterization of gene-environment interactions for colorectal cancer susceptibility loci
[PMID 22532847] Pooled Sample-Based GWAS: A Cost-Effective Alternative for Identifying Colorectal and Prostate Cancer Risk Variants in the Polish Population
[PMID 19010329] Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome.
[PMID 19011631] Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
[PMID 20501757] Low-penetrance susceptibility variants in familial colorectal cancer.
[PMID 20648012] Association studies on 11 published colorectal cancer risk loci.
[PMID 21071539] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
[PMID 21314996] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.
[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.
[PMID 23359760] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 22987364] Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers.
[PMID 22999960] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.
[PMID 23434150] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
[PMID 24875374] Variation in the Association Between Colorectal Cancer Susceptibility Loci and Colorectal Polyps by Polyp Type
[PMID 25293934] Quantitative assessment of the influence of common variation rs16892766 at 8q23.3 with colorectal adenoma and cancer susceptibility
[PMID 25873010] Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk
[PMID 26885031] Association of 8q23-24 region (8q23.3 loci and 8q24.21 loci) with susceptibility to colorectal cancer: a systematic and updated meta-analysis.
