rs16901979
| risk for prostate cancer |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2.9 | 1.5x increased risk for prostate cancer |
| (A;C) | 2.9 | 1.5x increased risk for prostate cancer |
| (C;C) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 127112671 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs16901979 |
| dbSNP (classic) | rs16901979 |
| ClinGen | rs16901979 |
| ebi | rs16901979 |
| HLI | rs16901979 |
| Exac | rs16901979 |
| Gnomad | rs16901979 |
| Varsome | rs16901979 |
| LitVar | rs16901979 |
| Map | rs16901979 |
| PheGenI | rs16901979 |
| Biobank | rs16901979 |
| 1000 genomes | rs16901979 |
| hgdp | rs16901979 |
| ensembl | rs16901979 |
| geneview | rs16901979 |
| scholar | rs16901979 |
| rs16901979 | |
| pharmgkb | rs16901979 |
| gwascentral | rs16901979 |
| openSNP | rs16901979 |
| 23andMe | rs16901979 |
| SNPshot | rs16901979 |
| SNPdbe | rs16901979 |
| MSV3d | rs16901979 |
| GWAS Ctlg | rs16901979 |
| GMAF | 0.18 |
| Max Magnitude | 2.9 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
| This SNP has been recognized by the Coriell Personalized Medicine Collaborative ICOB.
|
rs16901979 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies. In some studies, the regions have been divided, and this SNP falls in region 2.
In a study of over 3,600 Caucasians with prostate cancer, rs16901979 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs16901979(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.53 (CI: 1.22-1.92, p=1.8x10e-4) and may account for 3.6% of population attributable risk.10.1056/NEJMoa075819
cancer related according to this blog
Two genetic markers in the 8q24 region of chromosome 8 rs7008482 and rs16901979 have been linked to an increased risk of prostate cancer in African Americans. abstract
In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 2) of advanced prostate cancer.[PMID 18231127
]
A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs16901979(A) allele carriers is 1.74 (CI: 1.72-1.77).[PMID 18231127]
| GWAS | |
|---|---|
| SNP | rs16901979 |
| PubMedID | [PMID 17401366] |
| Condition | Prostate cancer |
| Gene | Intergenic |
| Risk Allele | A |
| pValue | 1.00E-012 |
| OR | 1.79 |
| 95% CI | 1.53-2.11) (EA |
[PMID 19549807] Prostate Cancer Risk Associated Loci in African Americans
[PMID 19562729] Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry
| GWAS snp | |
|---|---|
| PMID | [PMID 19767754]
|
| Trait | Prostate cancer |
| Title | Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility |
| Risk Allele | A |
| P-val | 3E-14 |
| Odds Ratio | 1.80 [1.55-2.09] |
[PMID 19908238] Common variants at 8q24 are associated with prostate cancer risk in Taiwanese men
[PMID 20564319] Prostate cancer risk-associated variants reported from genome-wide association studies: Meta-analysis and their contribution to genetic Variation
[PMID 20717903] Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: The flint men's health study
[PMID 21229559] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry
[PMID 21820706] Prostate Cancer Risk Alleles and Their Associations With Other Malignancies
[PMID 21756274] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men
[PMID 22067658] Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders
[PMID 22234922] 8q24 risk alleles in West African and Caribbean men
[PMID 22303333] Replication of GWAS "Hits" by Race for Breast and Prostate Cancers in European Americans and African Americans
[PMID 22583965] Association of common variations of 8q24 with the risk of prostate cancer in Koreans and a review of the Asian population
[PMID 17978284] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.
[PMID 18213635] Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.
[PMID 18274536] Genome-wide association studies: progress and potential for drug discovery and development.
[PMID 18360876] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.
[PMID 18423739] Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles.
[PMID 18491292] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18682823] Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.
[PMID 18768484] Family-based samples can play an important role in genetic association studies.
[PMID 18768513] Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.
[PMID 18794092] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
[PMID 18990762] Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.
[PMID 19058137] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.
[PMID 19104501] Prostate cancer genomics: towards a new understanding.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 19528667] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
[PMID 19602258] Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20133699] Long-range enhancers on 8q24 regulate c-Myc.
[PMID 20584312] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 20823317] is-rSNP: a novel technique for in silico regulatory SNP detection.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21445969] Significant associations of prostate cancer susceptibility variants with survival in patients treated with androgen-deprivation therapy.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
[PMID 21557270] Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry.
[PMID 22382457] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.
[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
[PMID 24345439] Prostate cancer risk alleles are associated with prostate cancer tumor volume and prostate size
[PMID 22848662] Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese.
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 25252079] 8q24 risk alleles and prostate cancer in African-Barbadian men
[PMID 25684153] A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation
[PMID 32341752] Association of germline genetic variants with TMPRSS2-ERG fusion status in prostate cancer.
[PMID 32295536] Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.
