rs17234657
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | |
| (G;G) | 2.3x risk | |
| (G;T) | 1.5x risk | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 40401407 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs17234657 |
| dbSNP (classic) | rs17234657 |
| ClinGen | rs17234657 |
| ebi | rs17234657 |
| HLI | rs17234657 |
| Exac | rs17234657 |
| Gnomad | rs17234657 |
| Varsome | rs17234657 |
| LitVar | rs17234657 |
| Map | rs17234657 |
| PheGenI | rs17234657 |
| Biobank | rs17234657 |
| 1000 genomes | rs17234657 |
| hgdp | rs17234657 |
| ensembl | rs17234657 |
| geneview | rs17234657 |
| scholar | rs17234657 |
| rs17234657 | |
| pharmgkb | rs17234657 |
| gwascentral | rs17234657 |
| openSNP | rs17234657 |
| 23andMe | rs17234657 |
| SNPshot | rs17234657 |
| SNPdbe | rs17234657 |
| MSV3d | rs17234657 |
| GWAS Ctlg | rs17234657 |
| GMAF | 0.1097 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs17234657 has been reported in a large study to be associated with Crohn's disease. [PMID 17554261
]
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.54 (CI 1.34-1.76), and for homozygotes, 2.32 (CI 1.59-3.39). [PMID 17554300]
[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 20335276] PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations.
[PMID 20561984] Study of chromosomal region 5p13.1 in Crohn's disease, ulcerative colitis, and rheumatoid arthritis.
