rs17445836 is a SNP in the region of the IRF8 gene.
A large study (~5,000 patients) found an increased risk for multiple sclerosis associated with rs17445836; the odds ratio for the minor allele was reported as 0.80 (CI: 0.72-0.89, p=3.73x10(-9)).10.1038/ng.401
| GWAS snp
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| PMID
|
[PMID 19525953 ]
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| Trait
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Multiple sclerosis
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| Title
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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
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| Risk Allele
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G
|
| P-val
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4E-9
|
| Odds Ratio
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1.25 [1.12-1.39]
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[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
[PMID 23965942] Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis
[PMID 25989711] Association of IRF8 gene polymorphisms with autoimmune thyroid disease
]
