rs1799969
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | slightly higher breast cancer risk | |
| (A;G) | slightly higher breast cancer risk | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 10284116 |
| Gene | ICAM1, LOC105372272 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1799969 |
| dbSNP (classic) | rs1799969 |
| ClinGen | rs1799969 |
| ebi | rs1799969 |
| HLI | rs1799969 |
| Exac | rs1799969 |
| Gnomad | rs1799969 |
| Varsome | rs1799969 |
| LitVar | rs1799969 |
| Map | rs1799969 |
| PheGenI | rs1799969 |
| Biobank | rs1799969 |
| 1000 genomes | rs1799969 |
| hgdp | rs1799969 |
| ensembl | rs1799969 |
| geneview | rs1799969 |
| scholar | rs1799969 |
| rs1799969 | |
| pharmgkb | rs1799969 |
| gwascentral | rs1799969 |
| openSNP | rs1799969 |
| 23andMe | rs1799969 |
| SNPshot | rs1799969 |
| SNPdbe | rs1799969 |
| MSV3d | rs1799969 |
| GWAS Ctlg | rs1799969 |
| GMAF | 0.07071 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1799969, also known as G241R or +241G/A, is a SNP in the ICAM1 gene. The more common (G) allele encodes the glycine (G).
A study of 276 Iranian breast cancer patients concluded (p = 0.008) that rs1799969(A) allele carriers may have a higher risk of developing breast cancer.[PMID 18474291]
| GWAS | |
|---|---|
| SNP | rs1799969 |
| PubMedID | [PMID 18604267 ]
|
| Condition | Soluble ICAM-1 |
| Gene | ICAM1 |
| Risk Allele | G |
| pValue | 4.00E-047 |
| OR | 28.19 |
| 95% CI | NR) umol/L decreas |
[PMID 19332210] Candidate genetic variants in the fibrinogen, methylenetetrahydrofolate reductase, and intercellular adhesion molecule-1 genes and plasma levels of fibrinogen, homocysteine, and intercellular adhesion molecule-1 among various race/ethnic groups: Data from the Women's Genome Health Study
[PMID 18420209] ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA)
[PMID 20031590] The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations
[PMID 20585554] On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
[PMID 21245421] Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma
| GWAS snp | |
|---|---|
| PMID | [PMID 21533024]
|
| Trait | |
| Title | Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. |
| Risk Allele | A |
| P-val | 1E-120 |
| Odds Ratio | 24.9000 [NR] ng/mL decrease |
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16385446] A testing framework for identifying susceptibility genes in the presence of epistasis.
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 17903293] Genome-wide association with select biomarker traits in the Framingham Heart Study.
[PMID 18045485] The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
[PMID 18505543] Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 18528404] Variation in the ICAM1 gene is not associated with severe malaria phenotypes.
[PMID 18703101] ICAM1 R241 is not associated with celiac disease in the Spanish population.
[PMID 18778477] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 22388798] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.
[PMID 24289603] Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors
