rs1799987

Orientation

plus

Stabilized

plus

Make rs1799987(A;A)

Make rs1799987(A;G)

Make rs1799987(G;G)

Reference

GRCh38 38.1/141

Chromosome

3

Position

46370444

Gene	CCR5, LOC102724297

is a	snp
is	mentioned by
dbSNP	rs1799987
dbSNP (classic)	rs1799987
ClinGen	rs1799987
ebi	rs1799987
HLI	rs1799987
Exac	rs1799987
Gnomad	rs1799987
Varsome	rs1799987
LitVar	rs1799987
Map	rs1799987
PheGenI	rs1799987
Biobank	rs1799987
1000 genomes	rs1799987
hgdp	rs1799987
ensembl	rs1799987
geneview	rs1799987
scholar	rs1799987
google	rs1799987
pharmgkb	rs1799987
gwascentral	rs1799987
openSNP	rs1799987
23andMe	rs1799987
SNPshot	rs1799987
SNPdbe	rs1799987
MSV3d	rs1799987
GWAS Ctlg	rs1799987

GMAF

0.4871

Max Magnitude

0

CCR5 59029G, also known as -2459 [PMID 9742978, PMID 12815099]

[PMID 22146622] Polymorphisms of CCL3L1/CCR5 genes and recurrence of hepatitis B in liver transplant recipients

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 17079285] Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence.

[PMID 17672867] Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.

[PMID 17984846] Single nucleotide polymorphism of CC chemokine ligand 5 promoter gene in recipients may predict the risk of chronic graft-versus-host disease and its severity after allogeneic transplantation.

[PMID 18182569] Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group.

[PMID 18633107] G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19225544] Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 20206716] Genetic variation within the gene encoding the HIV-1 CCR5 coreceptor in two South African populations.

[PMID 20487506] A whole genome association study of mother-to-child transmission of HIV in Malawi.

[PMID 20552027] Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.

[PMID 21091093] Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population.

[PMID 22924548] CCR5 gene polymorphism is a genetic risk factor for radiographic severity of rheumatoid arthritis.

ClinVar
Risk	rs1799987(G;G)
Alt	rs1799987(G;G)
Reference	rs1799987(A;A)
Significance	Other
Disease	Acquired immunodeficiency syndrome CCR5 PROMOTER POLYMORPHISM Human immunodeficiency virus type 1
Variation	info
Gene	LOC102724297 CCR5
CLNDBN	Acquired immunodeficiency syndrome, delayed progression to CCR5 PROMOTER POLYMORPHISM Human immunodeficiency virus type 1, susceptibility to
Reversed	0
HGVS	NC_000003.11:g.46411935A>G
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000008671.2, RCV000008674.2, RCV000008675.4,

[PMID 29696014] Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas' Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy.