rs1800872

Orientation

minus

Stabilized

minus

Make rs1800872(A;A)

Make rs1800872(A;C)

Make rs1800872(C;C)

Reference

GRCh38 38.1/141

Chromosome

1

Position

206773062

Gene

IL10

is a	snp
is	mentioned by
dbSNP	rs1800872
dbSNP (classic)	rs1800872
ClinGen	rs1800872
ebi	rs1800872
HLI	rs1800872
Exac	rs1800872
Gnomad	rs1800872
Varsome	rs1800872
LitVar	rs1800872
Map	rs1800872
PheGenI	rs1800872
Biobank	rs1800872
1000 genomes	rs1800872
hgdp	rs1800872
ensembl	rs1800872
geneview	rs1800872
scholar	rs1800872
google	rs1800872
pharmgkb	rs1800872
gwascentral	rs1800872
openSNP	rs1800872
23andMe	rs1800872
SNPshot	rs1800872
SNPdbe	rs1800872
MSV3d	rs1800872
GWAS Ctlg	rs1800872

GMAF

0.4091

Max Magnitude

0

?	(A;A) (A;C) (C;C)	28

The IL10 C627A polymorphism in the anti-inflammatory Interleukin 10 gene decreases gene transcription.

Effect of Interleukin-10 Gene Polymorphisms on Clinical Outcome of Patients with Aggressive Non-Hodgkin's Lymphoma. An exploratory study with negative results.

[PMID 19208551] rs1800872(A) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies.

[PMID 19276283] Interaction between BCL2 and Interleukin-10 Gene Polymorphisms Alter Outcomes of Diffuse Large B-Cell Lymphoma following Rituximab Plus CHOP Chemotherapy

[PMID 19386798] Relevance of gamma interferon, tumor necrosis factor alpha, and interleukin-10 gene polymorphisms to susceptibility to Mediterranean spotted fever

[PMID 19700159] Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study

[PMID 20031567] An Evaluation of Candidate Genes of Inflammation and Thrombosis in Relation to the Risk of Venous Thromboembolism: The Women's Genome Health Study

[PMID 20388104] Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications

[PMID 20509889] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

[PMID 20927126] Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

[PMID 21211963] Lack of association of IL-10 gene polymorphisms with prostate cancer: Evidence from 11,581 subjects

[PMID 21239167] TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer

[PMID 21609779] Association of TNF-? and IL-10 polymorphisms with tuberculosis in Tunisian populations

[PMID 21855833] Replication of Genetic Association Studies in Aortic Stenosis in Adults

[PMID 21917900] Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform

[PMID 22479352] The Role of Inflammatory Pathway Genetic Variation on Maternal Metabolic Phenotypes during Pregnancy

[PMID 22594912] Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

[PMID 22666399] Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study

[PMID 22715992] Association of interleukin-10 gene promoter polymorphism in allergic patients

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16600026] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

[PMID 16672072] The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome.

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16846490] Lemierre's syndrome and genetic polymorphisms: a case report.

[PMID 16959027] Novel IL10 gene family associations with systemic juvenile idiopathic arthritis.

[PMID 17215862] The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17552041] Influence of interleukin 10 promoter polymorphisms in susceptibility to giant cell arteritis in Northwestern Spain.

[PMID 17592300] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.

[PMID 17665434] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17929139] Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia.

[PMID 17980158] Genetic variation in interleukin-10 gene and risk of oral cancer.

[PMID 18307517] Common studied polymorphisms do not affect plasma cytokine levels upon endotoxin exposure in humans.

[PMID 18479293] Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.

[PMID 18559596] Effect of interleukin-10 gene polymorphisms on clinical outcome of patients with aggressive non-Hodgkin's lymphoma: an exploratory study.

[PMID 18598732] Vaccine immunogenetics: bedside to bench to population.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19087313] Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19264973] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19347053] Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

[PMID 19409109] Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

[PMID 19412539] IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB.

[PMID 19458621] Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case--control study.

[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19604093] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

[PMID 19673019] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

[PMID 19852851] Asthma and genes encoding components of the vitamin D pathway.

[PMID 19907653] Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population.

[PMID 19934104] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

[PMID 20041166] Common genetic variation and the control of HIV-1 in humans.

[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

[PMID 20299965] Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study.

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20525402] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 20725607] CCL3 genotype and current depression increase risk of HIV-associated dementia.

[PMID 20737205] The associations between two polymorphisms in the interleukin-10 gene promoter and breast cancer risk.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20865317] Lack of association between two SNPs (rs1800896 and rs1800872) in IL-10 gene promoter and breast cancer in Caucasians.

[PMID 21354456] The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.

[PMID 21424183] An association of interleukin-10 gene polymorphisms with Graves' disease in two Chinese populations.

[PMID 22239992] Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia.

[PMID 22372709] Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.

[PMID 22644143] The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.

[PMID 23079832] Meta-analysis of epidemiological studies of association of two polymorphisms in the interleukin-10 gene promoter and colorectal cancer risk

[PMID 23148667] The SNP at -592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development

[PMID 23235789] IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample

[PMID 22859398] Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence

[PMID 23668806] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

[PMID 23086128] Profiles of gene polymorphisms in cytokines and Toll-like receptors with higher risk for gastric cancer

[PMID 23840460] Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population

[PMID 23299779] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma

[PMID 23880623] Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4-infected Children

[PMID 23886125] Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects

[PMID 24040186] Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a chinese general population

[PMID 24060592] The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients

[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

[PMID 24128120] The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis

[PMID 24151497] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria

[PMID 24194923] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study

[PMID 24327156] [Association of interleukin 10 gene -592C/A polymorphism with coronary artery disease]

[PMID 24449078] Association of interleukin-10 gene promoter polymorphisms with susceptibility to acute pyelonephritis in children

[PMID 24603720] Association of interleukin-10 polymorphisms with schizophrenia: a meta-analysis

[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.

[PMID 23133602] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.

[PMID 23430974] Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx.

[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 23640160] IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.

[PMID 23790189] Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population.

[PMID 24758873] Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

[PMID 24008079] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts

[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification

[PMID 24982395] Significant Association of Interleukin-10 Genotypes and Oral Cancer Susceptibility in Taiwan

[PMID 23951054] The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients

[PMID 25189915] Effects of Interleukin-10 Polymorphisms and Smoking on the Risk of Gastric Cancer in Taiwan

[PMID 25412954] Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma

[PMID 25735143] [Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction]

[PMID 25505294] The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection

[PMID 25503130] Interleukin-10 (IL-10) promoter genotypes are associated with lung cancer risk in Taiwan males and smokers

[PMID 26015771] Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population

[PMID 25376093] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children

[PMID 26198819] Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors

[PMID 26340474] Association of IL10 Polymorphisms and Leprosy: A Meta-Analysis

[PMID 26400525] Association between variants of IL-8 and IL-10 genes, and efficacy of transcatheter arterial chemoembolization and subsequent prognosis in patients with liver cancer

[PMID 26546526] The Contribution of Interleukin-10 Promoter Genotypes to Susceptibility to Asthma in Adults

[PMID 27210870] [Effects of IL10-592 locus of AA genotype on the incidence of aGVHD and survival after HLA-matched unrelated allogeneic hematopoietic stem cell transplantation].

[PMID 27228545] IL-10 gene polymorphism is associated with preschool atopy and early-life recurrent wheezing after bronchiolitis in infancy.

[PMID 27342690] Polymorphisms in STAT4, IL10, PSORS1C1, PTPN2 and MIR146A genes are differently associated with prognostic factors in Italian patients affected by Rheumatoid Arthritis.

[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.

[PMID 28359052] Association of Interleukin-10 Polymorphisms (rs1800872, rs1800871, and rs1800896) with Predisposition to IgA Nephropathy in a Chinese Han Population: A Case-Control Study.

[PMID 28385181] Genetic predisposition of IL-10 promoter polymorphisms with risk of multiple sclerosis: A meta-analysis.

[PMID 28763918] [The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City].

[PMID 28785144] Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.

[PMID 28980933] Predictive role of cytokines IL-10, IL-12 and TNF-α gene polymorphisms for the development of osteonecrosis of the femoral head in the Chinese Han population.

[PMID 29662655] Association of IL4, IL6, and IL10 polymorphisms with pulmonary tuberculosis in a Tibetan Chinese population.

[PMID 29666343] Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.

[PMID 30130760] Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization.

[PMID 30275190] IL-8-251T>A (rs4073) Polymorphism Is Associated with Prognosis in Gastric Cancer Patients.

[PMID 30430731] Interleukin 10 gene promoter polymorphisms (rs1800896, rs1800871 and rs1800872) and haplotypes are associated with the activity of systemic lupus erythematosus and IL10 levels in an Iranian population.

[PMID 30594267] Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort.

[PMID 30873205] Novel Interleukin-10 Gene Polymorphism Is Linked to Gestational Diabetes in Taiwanese Population.

[PMID 30882006] STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren's Syndrome: Association with Disease Susceptibility and Clinical Aspects.

[PMID 30998173] [Association between IL-10 Gene -592(C→A) (rs1800872) SNP and GVHD after Allogeneic Hematopoietic Stem Cell Transplantation in Children].

[PMID 31264107] Association between interleukin-4 and interleukin-10 single nucleotide polymorphisms and multiple sclerosis among Iraqi patients.

[PMID 31280929] Association study of single nucleotide polymorphisms in IL-10 and IL-17 genes with the severity of microbial keratitis.

[PMID 31637197] Association between interleukin-10 genetic polymorphisms and risk of primary open angle glaucoma in a Chinese Han population: a case-control study.

[PMID 31816580] Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis.

[PMID 32046104] The Impact of IL-6 and IL-10 Gene Polymorphisms in Diffuse Large B-Cell Lymphoma Risk and Overall Survival in an Arab Population: A Case-Control Study.

[PMID 32124801] SNPs and transcriptional activity of genes of innate and adaptive immunity at the maternal-fetal interface in woman with preterm labour, associated with preterm premature rupture of membranes.

[PMID 32319410] [Relationship between Single Nucleotide Polymorphisms of IL2RA, IL-10 Gene and Epstein-Barr Virus Associated Hemophagocytic Lymphohistiocytosisin in children].

[PMID 32744314] Investigation of IL-4, IL-10, and HVEM polymorphisms with esophageal squamous cell carcinoma: a case-control study involving 1,929 participants.