rs1876828
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in clinvar |
| Make rs1876828(A;A) |
| Make rs1876828(A;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 45834159 |
| Gene | CRHR1, CRHR1-IT1-CRHR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1876828 |
| dbSNP (classic) | rs1876828 |
| ClinGen | rs1876828 |
| ebi | rs1876828 |
| HLI | rs1876828 |
| Exac | rs1876828 |
| Gnomad | rs1876828 |
| Varsome | rs1876828 |
| LitVar | rs1876828 |
| Map | rs1876828 |
| PheGenI | rs1876828 |
| Biobank | rs1876828 |
| 1000 genomes | rs1876828 |
| hgdp | rs1876828 |
| ensembl | rs1876828 |
| geneview | rs1876828 |
| scholar | rs1876828 |
| rs1876828 | |
| pharmgkb | rs1876828 |
| gwascentral | rs1876828 |
| openSNP | rs1876828 |
| 23andMe | rs1876828 |
| SNPshot | rs1876828 |
| SNPdbe | rs1876828 |
| MSV3d | rs1876828 |
| GWAS Ctlg | rs1876828 |
| GMAF | 0.1162 |
| Max Magnitude | 0 |
[PMID 18565889] The G allele at the rs1876828 SNP was associated with lower z scores (P = .02) in males but tended to have the opposite association in females (P = .09). CRHR1 polymorphisms may impact the risk of bone density deficits in patients treated with corticosteroids and antimetabolites in a sex-specific manner.
[PMID 15365580] Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans.
[PMID 19750552
] Risk and resilience: genetic and environmental influences on development of the stress response.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 22641026] Predicting inhaled corticosteroid response in asthma with two associated SNPs.
[PMID 23726670] Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum
| ClinVar | |
|---|---|
| Risk | rs1876828(A;A) |
| Alt | rs1876828(A;A) |
| Reference | Rs1876828(G;G) |
| Significance | Drug-response |
| Disease | triamcinolone response - Efficacy corticosteroids response - Efficacy fluticasone propionate response - Efficacy fluticasone/salmeterol response - Efficacy budesonide response - Efficacy |
| Variation | info |
| Gene | CRHR1-IT1-CRHR1 CRHR1 |
| CLNDBN | triamcinolone response - Efficacy corticosteroids response - Efficacy fluticasone propionate response - Efficacy fluticasone/salmeterol response - Efficacy budesonide response - Efficacy |
| Reversed | 1 |
| HGVS | NC_000017.10:g.43911525C>T |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211182.1, RCV000211194.1, RCV000211279.1, RCV000211365.1, RCV000211373.1, |
