rs1898830
| Orientation | plus |
| Stabilized | plus |
| Make rs1898830(A;A) |
| Make rs1898830(A;G) |
| Make rs1898830(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 153687301 |
| Gene | TLR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1898830 |
| dbSNP (classic) | rs1898830 |
| ClinGen | rs1898830 |
| ebi | rs1898830 |
| HLI | rs1898830 |
| Exac | rs1898830 |
| Gnomad | rs1898830 |
| Varsome | rs1898830 |
| LitVar | rs1898830 |
| Map | rs1898830 |
| PheGenI | rs1898830 |
| Biobank | rs1898830 |
| 1000 genomes | rs1898830 |
| hgdp | rs1898830 |
| ensembl | rs1898830 |
| geneview | rs1898830 |
| scholar | rs1898830 |
| rs1898830 | |
| pharmgkb | rs1898830 |
| gwascentral | rs1898830 |
| openSNP | rs1898830 |
| 23andMe | rs1898830 |
| SNPshot | rs1898830 |
| SNPdbe | rs1898830 |
| MSV3d | rs1898830 |
| GWAS Ctlg | rs1898830 |
| GMAF | 0.3466 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1898830, known as -15607A/G and located in the first intron of the TLR2 gene, is associated with an increased risk for shedding and lesion frequency of genital herpes simplex virus type 2 HSV-2 outbreaks.[PMID 17624834]
The risk allele is (G).
Note that the increased risk is not that great; median shedding rate was 16.7% for (G) allele carriers vs 12.0% when it was absent (= risk ratio for a dominant effect of 1.60), and the median lesional rate was 10.4% for (G) carriers vs 5.3% for non-carriers (risk ratio 2.16). [PMID 17624834]
[PMID 20577149] IDENTIFICATION OF HAPLOTYPE TAG SNPS WITHIN THE ENTIRE TLR2 GENE AND THEIR CLINICAL RELEVANCE IN PATIENTS WITH MAJOR TRAUMA
[PMID 21371045] TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy
[PMID 18396467
] Genetic variation and haplotype structures of innate immunity genes in eastern India.
[PMID 19543401] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
[PMID 20057905] Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
[PMID 20113509] Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.
[PMID 20227302] Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.
[PMID 21437199] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.
[PMID 23657238] Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent
[PMID 23021866] Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents
[PMID 23906542] Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease
[PMID 23161283] SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis?
[PMID 25928077] Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population
[PMID 28703296] Correlation between TLR2, TLR3, TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns.
