Have questions? Visit https://www.reddit.com/r/SNPedia

rs200185429

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
(C;T) 3 Lower type-2 diabetes risk
Make rs200185429(T;T)
ReferenceGRCh38.p7 38.3/151
Chromosome8
Position117153084
GeneLOC105375716, SLC30A8
is asnp
is mentioned by
dbSNPrs200185429
dbSNP (classic)rs200185429
ClinGenrs200185429
ebirs200185429
HLIrs200185429
Exacrs200185429
Gnomadrs200185429
Varsomers200185429
LitVarrs200185429
Maprs200185429
PheGenIrs200185429
Biobankrs200185429
1000 genomesrs200185429
hgdprs200185429
ensemblrs200185429
geneviewrs200185429
scholarrs200185429
googlers200185429
pharmgkbrs200185429
gwascentralrs200185429
openSNPrs200185429
23andMers200185429
23andMe allrs200185429
SNPshotrs200185429
SNPdbers200185429
MSV3drs200185429
GWAS Ctlgrs200185429
Max Magnitude3

rs200185429, also known as c.412C>T, p.Arg138Ter and R138X, is perhaps the best studied of over 10 loss-of-function variants found in the SLC30A8 gene to reduce risk of developing type-2 diabetes by about 2/3rds (OR:0.34, p=1.7×10e−6) in a large Icelandic study published in 2014.[PMID 24584071OA-icon.png]