rs2071746
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | normal | |
| (A;T) | normal | |
| (T;T) | may be part of gs124 |
| Reference | GRCh38 38.1/141 |
| Chromosome | 22 |
| Position | 35380679 |
| Gene | HMOX1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2071746 |
| dbSNP (classic) | rs2071746 |
| ClinGen | rs2071746 |
| ebi | rs2071746 |
| HLI | rs2071746 |
| Exac | rs2071746 |
| Gnomad | rs2071746 |
| Varsome | rs2071746 |
| LitVar | rs2071746 |
| Map | rs2071746 |
| PheGenI | rs2071746 |
| Biobank | rs2071746 |
| 1000 genomes | rs2071746 |
| hgdp | rs2071746 |
| ensembl | rs2071746 |
| geneview | rs2071746 |
| scholar | rs2071746 |
| rs2071746 | |
| pharmgkb | rs2071746 |
| gwascentral | rs2071746 |
| openSNP | rs2071746 |
| 23andMe | rs2071746 |
| SNPshot | rs2071746 |
| SNPdbe | rs2071746 |
| MSV3d | rs2071746 |
| GWAS Ctlg | rs2071746 |
| GMAF | 0.4995 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
A case-control study of 300 patients with Alzheimer's disease found that subjects carrying both the rs2071746(T;T) and rs242557(A;A) genotypes had a 6.65x increased risk (CI: 1.12-39.29; p = 0.037) compared to subjects without these risk genotypes.[PMID 18841019]
This combination of SNPs is encapsulated in the gs124 genoset.
[PMID 20039940] Synergistic effect of two oxidative stress-related genes (heme oxygenase-1 and GSK3beta) on the risk of Parkinson's disease
[PMID 20509889
] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
[PMID 20190330] HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction
[PMID 21191307] Heme oxygenase-1 polymorphism is not associated with riskof colorectal cancer: a Danish prospective study
[PMID 21902835] Effect of Heme Oxygenase-1 Polymorphisms on Lung Function and Gene Expression
[PMID 22666428] Genetic Analyses of Heme Oxygenase 1 (HMOX1) in Different Forms of Pancreatitis
[PMID 18597895] Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.
[PMID 18640487] Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation.
[PMID 19406964] Association of genetic variants with chronic kidney disease in Japanese individuals.
[PMID 19526221] Heme oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome.
[PMID 20597111] Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis.
[PMID 21270830] Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection.
[PMID 21275653] Association of heme oxygenase-1 gene polymorphisms with essential hypertension and blood pressure in the Chinese Han population.
[PMID 23042203] Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis
[PMID 23725037] Polymorphism in the HMOX1 Gene is Associated with High Levels of Fetal Hemoglobin in Brazilian Patients with Sickle Cell Anemia
[PMID 22609818] Genetic polymorphisms of HO-1 and COX-1 are associated with aspirin resistance defined by light transmittance aggregation in Chinese Han patients
[PMID 25016572] Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke
[PMID 26173399] Heme oxygenase-1 promoter polymorphisms and risk of spina bifida
[PMID 26313808] Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Restless Legs Syndrome
[PMID 26868429] Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.
[PMID 27222475] Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations.
[PMID 28179208] Association between a heme oxygenase-2 genetic variant and risk of Parkinson's disease in Han Chinese.
[PMID 28276576] Delta-amino-levulinic acid dehydratase gene and essential tremor.
[PMID 28444966] Correlation between genetic polymorphisms within the MAPK1/HIF-1/HO-1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease.
[PMID 28785144] Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.
[PMID 29877949] Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis.
[PMID 32059452] Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients.
[PMID 32141648] Association of heme oxygenase-1 single nucleotide polymorphisms with susceptibility to tuberculosis in Chinese Han population.
