rs2165870

plus

Geno	Mag	Summary
(A;A)	2	2x higher risk for post-operative nausea
(A;G)	2	2x higher risk for post-operative nausea
(G;G)	0

Reference

GRCh38 38.1/141

Chromosome

1

Position

239622120

Gene	CHRM3, LOC105373225

is a	snp
is	mentioned by
dbSNP	rs2165870
dbSNP (classic)	rs2165870
ClinGen	rs2165870
ebi	rs2165870
HLI	rs2165870
Exac	rs2165870
Gnomad	rs2165870
Varsome	rs2165870
LitVar	rs2165870
Map	rs2165870
PheGenI	rs2165870
Biobank	rs2165870
1000 genomes	rs2165870
hgdp	rs2165870
ensembl	rs2165870
geneview	rs2165870
scholar	rs2165870
google	rs2165870
pharmgkb	rs2165870
gwascentral	rs2165870
openSNP	rs2165870
23andMe	rs2165870
SNPshot	rs2165870
SNPdbe	rs2165870
MSV3d	rs2165870
GWAS Ctlg	rs2165870

GMAF

0.2397

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

rs2165870 is a SNP in or near the promoter region of the muscarinic acetylcholine receptor 3 subtype CHRM3 gene on ch 1.

A GWAS study of 300+ patients exhibiting post-operative nausea found that carriers of rs2165870(A) alleles were at 2.3x higher risk for nausea (CI: 1.36 - 4, p = 0.002).[PMID 21694509]

rs2355230 is said to be a perfect proxy (r2 = 1) for rs2165870. [PMID 17903301 ] Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.

[PMID 31077873] Genetic contribution to PONV risk.

[PMID 32371828] Genetic variability in postoperative nausea and vomiting: A systematic review.