rs2239633

May influence risk of childhood B-cell acute lymphoblastic leukemia

minus

Geno	Mag	Summary
(C;C)

Make rs2239633(C;T)

Make rs2239633(T;T)

Reference

GRCh38 38.1/141

Chromosome

14

Position

23119848

Gene

CEBPE

is a	snp
is	mentioned by
dbSNP	rs2239633
dbSNP (classic)	rs2239633
ClinGen	rs2239633
ebi	rs2239633
HLI	rs2239633
Exac	rs2239633
Gnomad	rs2239633
Varsome	rs2239633
LitVar	rs2239633
Map	rs2239633
PheGenI	rs2239633
Biobank	rs2239633
1000 genomes	rs2239633
hgdp	rs2239633
ensembl	rs2239633
geneview	rs2239633
scholar	rs2239633
google	rs2239633
pharmgkb	rs2239633
gwascentral	rs2239633
openSNP	rs2239633
23andMe	rs2239633
SNPshot	rs2239633
SNPdbe	rs2239633
MSV3d	rs2239633
GWAS Ctlg	rs2239633

GMAF

0.3848

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

GWAS snp
PMID	[PMID 19684604 ]
Trait	Acute lymphoblastic leukemia (childhood)
Title	Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
Risk Allele	G
P-val	3E-7
Odds Ratio	1.34 [1.22-1.45]

OMIM	613065
Desc
Variant
Related	also

[PMID 22422485 ] Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report

[PMID 20919861] Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence.

[PMID 24564228 ] ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

GWAS snp
PMID	[PMID 23996088]
Trait	Acute lymphoblastic leukemia (B-cell precursor)
Title	Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
Risk Allele
P-val	1E-16
Odds Ratio	NR NR

[PMID 26177813] Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population

[PMID 26388693 ] A common genetic variation in CEBPE and acute lymphoblastic leukemia: a meta-analysis of the available evidence

[PMID 26575185 ] Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA

[PMID 27279837 ] Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population.

[PMID 28768142] Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.